DegronMD - P17302(GJA1)

GO - Biological processes (BP): adult heart development [GO:0007512]; atrial cardiac muscle cell action potential [GO:0086014]; atrial ventricular junction remodeling [GO:0003294]; blood vessel morphogenesis [GO:0048514]; bone development [GO:0060348]; bone remodeling [GO:0046849]; cardiac conduction system development [GO:0003161]; cell-cell signaling [GO:0007267]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular protein localization [GO:0034613]; cellular response to amyloid-beta [GO:1904646]; cellular response to pH [GO:0071467]; embryonic digit morphogenesis [GO:0042733]; epithelial cell maturation [GO:0002070]; establishment of mitotic spindle orientation [GO:0000132]; export across plasma membrane [GO:0140115]; gap junction assembly [GO:0016264]; glutamate secretion [GO:0014047]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; ion transmembrane transport [GO:0034220]; lens development in camera-type eye [GO:0002088]; maintenance of blood-brain barrier [GO:0035633]; male gonad development [GO:0008584]; microtubule-based transport [GO:0099111]; milk ejection reflex [GO:0060156]; negative regulation of cell growth [GO:0030308]; negative regulation of gene expression [GO:0010629]; negative regulation of gonadotropin secretion [GO:0032277]; negative regulation of trophoblast cell migration [GO:1901164]; neuron migration [GO:0001764]; osteoblast differentiation [GO:0001649]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of mesodermal cell differentiation [GO:1905772]; positive regulation of morphogenesis of an epithelium [GO:1905332]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of striated muscle tissue development [GO:0045844]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of bone mineralization [GO:0030500]; regulation of bone remodeling [GO:0046850]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; skeletal muscle tissue regeneration [GO:0043403]; spermatogenesis [GO:0007283]; T cell proliferation [GO:0042098]; xenobiotic transport [GO:0042908] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V289L	TCGA-09-0369	OV	TCGA	PPGY	ITCH	283:286	Mutation rewiring degron network	0.25
p.V289L	DO30640	OV	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.25
p.A276T	TCGA-AC-A7VB	BRCA	TCGA	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.A276T	DO219595	BRCA	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.A276T	DO222884	COCA	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.A276T	DO233678	GACA	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.A276T	DO233713	GACA	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.A276T	DO23204	LINC	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.R293K	TCGA-CC-A3MB	LIHC	TCGA	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.R293K	DO23068	LIHC	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.S296F	TCGA-D9-A6EC	SKCM	TCGA	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5
p.S296F	DO50291	SKCM	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5
p.T275I	TCGA-EE-A29L	SKCM	TCGA	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5556
p.T275I	TCGA-EE-A2MT	SKCM	TCGA	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5556
p.T275I	DO222599	MELA	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5556
p.T275I	DO37835	SKCM	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5556
p.T275I	DO38051	SKCM	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5556
p.S296Y	TCGA-EO-A22X	UCEC	TCGA	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5
p.S296Y	DO43907	UCEC	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.5
p.G285V	DO223515	CLLE	ICGC	PPGY	ITCH	283:286	Mutation altering degron motif	0.6421
p.D292N	DO234350	ESAD	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1667
p.R293I	DO229027	LICA	ICGC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1389
p.T290N	DO229035	LICA	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.6667
p.T290I	DO230931	LUSC	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.6667
p.T290I	DO224548	LUSC	ICGC	PPGY	ITCH	283:286	Mutation blocking phosphorylation signal	0.6667
p.P284L	DO220906	MELA	ICGC	PPGY	ITCH	283:286	Mutation altering degron motif	0.7582
p.G291D	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1944
p.G291D	ACH-000920	Leukemia	CCLE	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1944
p.G291D	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1944
p.D292G	SIDM00852	Glioma	GDSC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1667
p.D292G	ACH-000389	Brain Cancer	CCLE	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1667
p.D292G	H4	central nervous system	COSMIC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.1667
p.V289G	ACH-000383	Esophageal Cancer	CCLE	PPGY	ITCH	283:286	Mutation rewiring degron network	0.25
p.V289G	OE33	oesophagus	COSMIC	PPGY	ITCH	283:286	Mutation rewiring degron network	0.25

Kaplan plot for GJA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GJA1

UniProt ID: P17302

Entrez ID: 2697

Protein name: Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GJA1 in