DegronMD - P20749(BCL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S396F	TCGA-73-7499	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0833
p.S396F	DO25340	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0833
p.I357M	TCGA-C5-A1MQ	CESC	TCGA	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1111
p.I357M	DO49001	CESC	ICGC	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1111
p.P373L	TCGA-EE-A2MR	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.P373L	TCGA-EE-A2MR	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0556
p.P373L	DO37819	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.P373L	DO37819	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0556
p.E384K	TCGA-VQ-A91D	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	383:387	Mutation altering degron motif	0.591
p.E384K	DO51783	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation altering degron motif	0.591
p.D372G	DO233780	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.25
p.R364Q	DO233867	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.A379T	DO233867	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.0556
p.A379T	DO233867	GACA	ICGC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.2222
p.P371S	DO11854	GBM	ICGC	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2778
p.D356Y	DO229026	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.0833
p.P383R	DO228163	PBCA	ICGC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation altering degron motif	0.7512
p.L389H	DO227750	PBCA	ICGC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.2778
p.S385N	SIDM01943	Colorectal Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation altering degron motif	0.7069
p.A397T	SIDM00690	Head and Neck Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0556
p.A397T	SIDM00068	Colorectal Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0556
p.A397T	SIDM00213	Thyroid Gland Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0556
p.S390N	SIDM00014	Colorectal Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.25
p.S390G	SIDM01045	Endometrial Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.25
p.S390G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.25
p.R388H	ACH-000942	Leukemia	CCLE	PESSS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.3056

Kaplan plot for BCL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCL3

UniProt ID: P20749

Entrez ID: 602

Protein name: B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCL3 in