DegronMD - P23193(TCEA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R145M	TCGA-A8-A08R	BRCA	TCGA	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.R132W	TCGA-AA-3982	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132W	ACH-000586	Lung Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132W	NCI-H1876	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R141Q	TCGA-BR-8363	STAD	TCGA	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.R132L	TCGA-CV-6953	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.S135R	TCGA-E6-A1LX	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.8538
p.R132Q	TCGA-HC-8265	PRAD	TCGA	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132Q	DO43154	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132Q	DO41572	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132Q	DO41133	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132Q	SIDM00789	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132Q	ACH-000997	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R132Q	HCT-15	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.R123Q	TCGA-L5-A4OI	ESCA	TCGA	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R124M	DO1255	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.R124W	DO228284	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.T133S	DO51783	STAD	ICGC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7116
p.D124N	SIDM00542	Glioblastoma	GDSC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.D124N	SIDM01594	Breast Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.D124N	SIDM01316	Ewing's Sarcoma	GDSC	APSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833

Kaplan plot for TCEA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCEA1

UniProt ID: P23193

Entrez ID: 6917

Protein name: Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCEA1 in