DegronMD - P23771(GATA3)

GO - Biological processes (BP): anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cardiac right ventricle morphogenesis [GO:0003215]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cellular response to BMP stimulus [GO:0071773]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-4 [GO:0071353]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; cochlea development [GO:0090102]; defense response [GO:0006952]; developmental growth [GO:0048589]; ear development [GO:0043583]; embryonic hemopoiesis [GO:0035162]; embryonic organ development [GO:0048568]; erythrocyte differentiation [GO:0030218]; gene expression [GO:0010467]; humoral immune response [GO:0006959]; immune system development [GO:0002520]; innate immune response [GO:0045087]; inner ear morphogenesis [GO:0042472]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lymphocyte migration [GO:0072676]; male gonad development [GO:0008584]; mast cell differentiation [GO:0060374]; mesenchymal to epithelial transition [GO:0060231]; mesonephros development [GO:0001823]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell motility [GO:2000146]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in mesonephros development [GO:2000607]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [GO:2000703]; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [GO:2000734]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephric duct formation [GO:0072179]; nephric duct morphogenesis [GO:0072178]; neuron migration [GO:0001764]; norepinephrine biosynthetic process [GO:0042421]; otic vesicle development [GO:0071599]; parathyroid gland development [GO:0060017]; parathyroid hormone secretion [GO:0035898]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of ureteric bud formation [GO:0072107]; post-embryonic development [GO:0009791]; pro-T cell differentiation [GO:0002572]; regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370]; regulation of cellular response to X-ray [GO:2000683]; regulation of cytokine production [GO:0001817]; regulation of epithelial cell differentiation [GO:0030856]; regulation of establishment of cell polarity [GO:2000114]; regulation of histone H3-K27 methylation [GO:0061085]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell differentiation [GO:0045064]; thymic T cell selection [GO:0045061]; thymus development [GO:0048538]; TOR signaling [GO:0031929]; type IV hypersensitivity [GO:0001806]; ureteric bud formation [GO:0060676]; ureter maturation [GO:0035799]; ureter morphogenesis [GO:0072197]; uterus development [GO:0060065]; ventricular septum development [GO:0003281] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P134T	TCGA-39-5011	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.P134T	DO27532	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.G128W	TCGA-44-5644	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.G128W	TCGA-56-7730	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.G128W	DO25153	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.G128W	DO26617	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.P223L	TCGA-96-8169	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.P223L	DO26737	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.P223L	ACH-001516	Cervical Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.A146T	TCGA-AG-3592	READ	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.A146T	DO37308	READ	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.S214L	TCGA-B5-A5OC	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7667
p.S214L	DO52405	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7667
p.M205I	TCGA-BR-8380	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.M205I	TCGA-EI-6917	READ	TCGA	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.M205I	DO36881	READ	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.M205I	DO47803	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.D54N	TCGA-DF-A2KU	UCEC	TCGA	PPYY	ITCH	61:64	Mutation rewiring degron network	0.1389
p.D54N	DO223286	UCEC	ICGC	PPYY	ITCH	61:64	Mutation rewiring degron network	0.1389
p.S138F	TCGA-E7-A541	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7982
p.S138F	DO44037	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7982
p.S140F	TCGA-EE-A29D	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.S140F	DO38123	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.G128R	TCGA-EQ-5647	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.G128R	DO38807	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.G128E	TCGA-ER-A19N	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.G128E	DO37452	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.S142L	TCGA-H7-A6C4	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.25
p.S142L	DO49995	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.25
p.S142L	DO51101	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.25
p.S213L	TCGA-K4-A6FZ	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7667
p.S213L	DO44045	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7667
p.S213L	SIDM01175	Other Sarcomas	GDSC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7667
p.S213L	ACH-002309	Sarcoma	CCLE	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7667
p.S213L	SW684	soft tissue	COSMIC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7667
p.Q56H	TCGA-R6-A6DN	ESCA	TCGA	PPYY	ITCH	61:64	Mutation rewiring degron network	0.1944
p.P135L	TCGA-ZF-A9R7	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7582
p.P135L	DO219064	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7582
p.H149P	DO228056	EOPC	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.R202C	DO223066	ESCA	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0833
p.A207T	DO233253	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.P134H	DO228212	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.G55C	DO229028	LICA	ICGC	PPYY	ITCH	61:64	Mutation rewiring degron network	0.1667
p.R202L	DO229008	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0833
p.V132I	DO45299	LIRI	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.25
p.G125S	DO51481	PACA	ICGC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.P224L	DO227931	PBCA	ICGC	ASSST	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0833
p.P62T	SIDM00177	Melanoma	GDSC	PPYY	ITCH	61:64	Mutation altering degron motif	0.7031
p.A146P	SIDM00930	Osteosarcoma	GDSC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.A146P	ACH-001715	Bone Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.A146P	CAL-72	bone	COSMIC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.S147N	SIDM01574	Plasma Cell Myeloma	GDSC	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1111
p.S147N	ACH-000588	Myeloma	CCLE	PASSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1111
p.G65E	ACH-000657	Ovarian Cancer	CCLE	PPYY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.G65R	ACH-000866	Lung Cancer	CCLE	PPYY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.S212P	ACH-001991	Primary	CCLE	ASSST	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.5641

Kaplan plot for GATA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GATA3

UniProt ID: P23771

Entrez ID: 2625

Protein name: Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GATA3 in