DegronMD - P24666(ACP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V52M	TCGA-13-0757	OV	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.V52M	DO229018	LICA	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.V52M	DO32576	OV	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.V52M	SIDM01770	Gastric Carcinoma	GDSC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.V52M	ACH-000908	Gastric Cancer	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.G53D	TCGA-D5-6930	COAD	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2222
p.S55F	TCGA-DK-AA6U	BLCA	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.S55F	DO219008	BLCA	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.R65I	TCGA-EE-A2MG	SKCM	TCGA	DYR	CBL_MET	57:59	Mutation substituting flanking lysine	0.2778
p.R65I	DO37421	SKCM	ICGC	DYR	CBL_MET	57:59	Mutation substituting flanking lysine	0.2778
p.R54P	TCGA-W3-AA1V	SKCM	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.25
p.R54P	DO51276	SKCM	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.25
p.E51Q	DO44293	CESC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.P55R	DO48191	ESCA	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.P55R	SIDM00377	Other Sarcomas	GDSC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.P55R	ACH-001655	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.P55R	SKN	soft tissue	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.G68C	DO229035	LICA	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.0833
p.G68C	DO229008	LICA	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.0833
p.D57Y	DO23765	LUAD	ICGC	DYR	CBL_MET	57:59	Mutation altering degron motif	0.7325
p.G49V	DO231086	LUSC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1111
p.A54V	DO51407	PRAD	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.25
p.A54V	DO43979	UCEC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.25
p.G68D	DO38336	STAD	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.0833
p.P56S	DO42023	UCEC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.P58S	SIDM00683	Prostate Carcinoma	GDSC	DYR	CBL_MET	57:59	Mutation altering degron motif	0.6752
p.P58S	ACH-000977	lymph node	CCLE	DYR	CBL_MET	57:59	Mutation altering degron motif	0.6752
p.P58S	LNCaP-Clone-FGC	prostate	COSMIC	DYR	CBL_MET	57:59	Mutation altering degron motif	0.6752
p.G68S	SIDM00625	Other Sarcomas	GDSC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.0833
p.G68S	ACH-000449	Sarcoma	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.0833
p.G68S	MES-SA	soft tissue	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.0833
p.N66Y	SIDM00130	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1389
p.N66Y	ACH-000138	Pancreatic Cancer	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1389
p.N66Y	CFPAC-1	pancreas	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1389
p.P56A	SIDM00488	Colorectal Carcinoma	GDSC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.P56A	SIDM00988	Kidney Carcinoma	GDSC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.P56A	CaR-1	large intestine	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.P56A	BFTC-909	kidney	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.I52T	ACH-000975	Lung Cancer	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.S48C	ACH-002508	Skin Cancer	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.0833
p.G60R	NCI-H2135	lung	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.Q66R	YT	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1389

Kaplan plot for ACP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACP1

UniProt ID: P24666

Entrez ID: 52

Protein name: Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACP1 in