DegronMD - P25490(YY1)

FUNCTION: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). {ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P248H	TCGA-A5-A0GI	UCEC	TCGA	PPDY	ITCH	248:251	Mutation altering degron motif	0.7694
p.P248H	DO41807	UCEC	ICGC	PPDY	ITCH	248:251	Mutation altering degron motif	0.7694
p.S247L	TCGA-BR-8591	STAD	TCGA	PPDY	ITCH	248:251	Mutation blocking phosphorylation signal	0.75
p.S247L	DO229036	LICA	ICGC	PPDY	ITCH	248:251	Mutation blocking phosphorylation signal	0.75
p.S247L	DO47973	STAD	ICGC	PPDY	ITCH	248:251	Mutation blocking phosphorylation signal	0.75
p.E245D	TCGA-D1-A17Q	UCEC	TCGA	PPDY	ITCH	248:251	Mutation rewiring degron network	0.25
p.E245D	DO41903	UCEC	ICGC	PPDY	ITCH	248:251	Mutation rewiring degron network	0.25
p.S252L	TCGA-K4-A4AB	BLCA	TCGA	PPDY	ITCH	248:251	Mutation rewiring degron network	0.3056
p.S252L	DO44039	BLCA	ICGC	PPDY	ITCH	248:251	Mutation rewiring degron network	0.3056
p.N246S	DO233869	GACA	ICGC	PPDY	ITCH	248:251	Mutation rewiring degron network	0.2778
p.P261A	ACH-001415	Bladder Cancer	CCLE	PPDY	ITCH	248:251	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YY1

UniProt ID: P25490

Entrez ID: 7528

Protein name: Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YY1 in