FUNCTION: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates ...
FUNCTION: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). {ECO:0000269|PubMed:11049757, ECO:0000269|PubMed:11134050, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:8316221, ECO:0000269|PubMed:8665924}.
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GO - Biological processes (BP):
dopamine catabolic process [GO:0042420]; hydrogen peroxide biosynthetic process [GO:0050665]; negative regulation of serotonin secretion [GO:0014063]; neurotransmitter catabolic process [GO:0042135]; positive regulation of dopamine metabolic process [GO:0045964]; response to aluminum ion [GO:0010044...
dopamine catabolic process [GO:0042420]; hydrogen peroxide biosynthetic process [GO:0050665]; negative regulation of serotonin secretion [GO:0014063]; neurotransmitter catabolic process [GO:0042135]; positive regulation of dopamine metabolic process [GO:0045964]; response to aluminum ion [GO:0010044]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; substantia nigra development [GO:0021762]
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GO - Molecular function (MF):
electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; monoamine oxidase activity [GO:0097621]; primary amine oxidase activity [GO:0008131]...
electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; monoamine oxidase activity [GO:0097621]; primary amine oxidase activity [GO:0008131]
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]...
integral component of membrane [GO:0016021]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]
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