DegronMD - P28908(TNFRSF8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P193S	TCGA-06-5416	GBM	TCGA	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.P193S	DO10880	GBM	ICGC	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.S349I	TCGA-A5-A0G1	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7341
p.S349I	DO42472	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7341
p.P181L	TCGA-A5-A0G2	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.P181L	DO41235	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.E343Q	TCGA-G2-A3IE	BLCA	TCGA	PASTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2778
p.E343Q	DO767	BLCA	ICGC	PASTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2778
p.E343K	TCGA-WE-A8ZT	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2778
p.E343K	DO51290	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2778
p.P184R	DO48302	ESCA	ICGC	PATSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7512
p.D357Y	DO229018	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1111
p.P350S	DO229456	SKCA	ICGC	PASTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.3056
p.E348K	DO37567	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7022
p.E348K	DO51276	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7022
p.P181Q	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.P181Q	ACH-000995	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.P181Q	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.T180P	ACH-000974	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2222
p.A187V	SNU-1040	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6936

Kaplan plot for TNFRSF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNFRSF8

UniProt ID: P28908

Entrez ID: 943

Protein name: Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNFRSF8 in