DegronMD - P29120(PCSK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R654W	TCGA-AG-3885	READ	TCGA	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2222
p.R654W	SIDM00576	Acute Myeloid Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2222
p.R654W	ACH-002290	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2222
p.R654W	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2222
p.V651I	TCGA-DC-6682	READ	TCGA	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.S645I	TCGA-QC-A7B5	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.S643T	DO228483	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S643T	DO230334	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S643T	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S643T	DO229013	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S643T	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S643T	DO229005	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S643T	DO228941	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S643T	DO229047	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.F653L	DO222626	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.F653L	DO41133	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.F653V	DO52434	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.N647K	DO18819	KIRC	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6918
p.L657M	DO228974	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1389
p.A644E	DO228978	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2778
p.L660M	DO229018	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.0556
p.Y650N	DO222702	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7059
p.E655K	DO222731	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.K639E	DO43907	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1389
p.A656T	DO41235	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.E651G	DO41488	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.S647R	SIDM01137	Pancreatic Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6316
p.S647R	ACH-000235	Pancreatic Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6316
p.S647R	PANC-04-03	pancreas	COSMIC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6316
p.P646S	SIDM00660	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6752
p.P646S	ACH-000985	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6752
p.P646S	LS-411N	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6752
p.K637T	SIDM00835	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation substituting flanking lysine	0.1944
p.K637T	ACH-000489	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation substituting flanking lysine	0.1944
p.K637T	SW1116	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation substituting flanking lysine	0.1944
p.T640A	SIDM01082	Oral Cavity Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667

Kaplan plot for PCSK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCSK1

UniProt ID: P29120

Entrez ID: 5122

Protein name: Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCSK1 in