DegronMD - P29372(MPG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S47T	TCGA-AO-A1KR	BRCA	TCGA	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.6005
p.S47T	DO4209	BRCA	ICGC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.6005
p.A38T	TCGA-AX-A0IU	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.A38T	DO40954	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.D50N	TCGA-AX-A3G8	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.3056
p.D50N	DO41014	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.3056
p.S48L	TCGA-EB-A3Y7	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7667
p.S48L	DO37499	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7667
p.D36N	TCGA-VQ-A8P5	STAD	TCGA	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0833
p.D36N	DO51763	STAD	ICGC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0833
p.D36N	ACH-000901	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0833
p.P47L	DO50687	ORCA	ICGC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7582
p.E43D	SIDM00781	Colorectal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2778
p.E43D	SIDM00826	Colorectal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2778
p.E43D	ACH-000248	Breast Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2778
p.A52S	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A52S	ACH-000945	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A52S	NCI-H650	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A35S	NCI-H650	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0556

Kaplan plot for MPG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPG

UniProt ID: P29372

Entrez ID: 4350

Protein name: DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPG in