DegronMD - P29401(TKT)

FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}.

GO - Biological processes (BP): glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; regulation of growth [GO:0040008]; ribose phosphate biosynthetic process [GO:0046390]

GO - Molecular function (MF): calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]

GO - Cellular component (CC): cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; vesicle [GO:0031982]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G282D	DO48523	KIRP	ICGC	ILATPPQE	DEG_SCF_FBW7_2	284:291	Mutation blocking ubiquitination signal	0.7222
p.M444V	SIDM00194	Colorectal Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00586	Hepatocellular Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00617	Hepatocellular Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00491	Thyroid Gland Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00535	Chondrosarcoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00057	Neuroblastoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00552	Rhabdomyosarcoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00350	Head and Neck Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00487	Colorectal Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00251	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00564	Ovarian Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00397	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00988	Kidney Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00363	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01018	Hodgkin's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01728	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01498	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208

Showing 1 to 20 of 42 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TKT

UniProt ID: P29401

Entrez ID: 7086

Protein name: Transketolase (TK) (EC 2.2.1.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TKT in