DegronMD - P29401(TKT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L293M	TCGA-A5-A0G1	UCEC	TCGA	ILATPPQE	DEG_SCF_FBW7_2	284:291	Mutation rewiring degron network	0.2778
p.A438T	TCGA-AP-A051	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.2778
p.Q280E	TCGA-D6-A6EM	HNSC	TCGA	ILATPPQE	DEG_SCF_FBW7_2	284:291	Mutation blocking phosphorylation signal	0.6667
p.R446Q	TCGA-DF-A2KN	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.2778
p.T295I	TCGA-ER-A42L	SKCM	TCGA	ILATPPQE	DEG_SCF_FBW7_2	284:291	Mutation blocking phosphorylation signal	0.6667
p.R446W	TCGA-FW-A3R5	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.2778
p.G275R	DO48411	BLCA	ICGC	ILATPPQE	DEG_SCF_FBW7_2	284:291	Mutation blocking phosphorylation signal	0.5278
p.D454E	DO20249	KIRC	ICGC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0556
p.G282D	DO48523	KIRP	ICGC	ILATPPQE	DEG_SCF_FBW7_2	284:291	Mutation blocking ubiquitination signal	0.7222
p.A445S	DO23316	LINC	ICGC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.3056
p.Y434C	DO34328	PACA	ICGC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.1667
p.M444V	SIDM00194	Colorectal Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00586	Hepatocellular Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00617	Hepatocellular Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00491	Thyroid Gland Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00535	Chondrosarcoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00057	Neuroblastoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00552	Rhabdomyosarcoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00350	Head and Neck Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00487	Colorectal Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00251	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00564	Ovarian Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00397	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00988	Kidney Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM00363	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01018	Hodgkin's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01728	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01498	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01573	Plasma Cell Myeloma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01587	Bladder Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.M444V	SIDM01443	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation altering degron motif	0.7208
p.F454I	SIDM01175	Other Sarcomas	GDSC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0556
p.F454I	SW684	soft tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0556
p.F446I	ACH-002309	Sarcoma	CCLE	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.2778
p.F446I	SW684	soft tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.2778
p.L453P	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.L453P	HGC-27	stomach	COSMIC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.L453P	GB-1	central nervous system	COSMIC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.L453P	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.F280I	SW684	soft tissue	COSMIC	ILATPPQE	DEG_SCF_FBW7_2	284:291	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for TKT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TKT

UniProt ID: P29401

Entrez ID: 7086

Protein name: Transketolase (TK) (EC 2.2.1.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TKT in