DegronMD - P29966(MARCKS)

MARCKS

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S132L	DO6332	CESC	ICGC	AASST	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.8778
p.S134T	DO233798	GACA	ICGC	AASST	DEG_SPOP_SBC_1	129:133	Mutation blocking phosphorylation signal	0.75
p.A127T	DO229234	THCA	ICGC	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.E125G	DO229240	THCA	ICGC	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2222
p.E123A	SIDM01141	Ovarian Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.E123A	ACH-000291	Ovarian Cancer	CCLE	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.P136L	SIDM00007	Other Solid Cancers	GDSC	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.P136L	ACH-001550	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.P136L	MCC13	skin	COSMIC	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.G124R	SIDM01059	Melanoma	GDSC	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.G124R	ACH-000915	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.E123K	ACH-000501	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc