DegronMD - P31249(HOXD3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G146R	TCGA-44-8120	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.G146R	DO45402	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.Q159H	TCGA-BS-A0UV	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1667
p.Q159H	DO42793	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1667
p.P162H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0833
p.P162H	ACH-002272	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0833
p.P162H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0833
p.S150F	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6871
p.S150F	ACH-000945	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6871
p.S150F	NCI-H650	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6871
p.S157N	SIDM00783	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.S157N	ACH-000971	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.S157N	HCT-116	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons