DegronMD - P32242(OTX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A142T	TCGA-B5-A11Y	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7139
p.A142T	DO40889	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7139
p.S145F	TCGA-CK-4951	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7982
p.S145F	DO10582	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7982
p.S145F	SIDM00847	Rhabdomyosarcoma	GDSC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7982
p.S145F	ACH-000169	Sarcoma	CCLE	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7982
p.S145F	RD	soft tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7982
p.G125S	TCGA-D1-A103	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.G125S	DO42312	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.S121F	TCGA-EB-A299	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.S121F	DO37794	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.S137L	TCGA-EO-A3AU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.6556
p.S137L	DO43827	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.6556
p.A131D	TCGA-IB-7651	PAAD	TCGA	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7793
p.A131D	DO46657	PAAD	ICGC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7793
p.P149L	DO222837	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.P149L	DO222837	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.A154D	DO229259	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.A151P	DO229221	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.G125C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.G125C	H513	pleura	COSMIC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.F127Y	SIDM00217	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.F127Y	SIDM00217	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.F127Y	ACH-000999	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.F127Y	ACH-000999	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.F127Y	SNU-1040	large intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.F127Y	SNU-1040	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.S144G	SIDM01612	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6993
p.S144G	ACH-000946	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6993
p.Q126E	SIDM01424	B-Lymphoblastic Leukemia	GDSC	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.Q126E	SIDM01424	B-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.Q126E	ACH-000782	Leukemia	CCLE	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.Q126E	ACH-000782	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.Q126E	ACH-001735	Leukemia	CCLE	AVSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.Q126E	ACH-001735	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556

Kaplan plot for OTX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTX1

UniProt ID: P32242

Entrez ID: 5013

Protein name: Homeobox protein OTX1 (Orthodenticle homolog 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTX1 in