DegronMD - P32246(CCR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S341Y	TCGA-06-5416	GBM	TCGA	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.8231
p.S341Y	DO10880	GBM	ICGC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.8231
p.H349R	TCGA-AA-3984	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1667
p.H349R	DO9002	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1667
p.P329S	TCGA-EB-A41A	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0556
p.P329S	DO37429	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0556
p.S341C	TCGA-LP-A7HU	CESC	TCGA	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.8652
p.S341C	DO51611	CESC	ICGC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.8652
p.R338T	TCGA-XQ-A8TA	PRAD	TCGA	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.R338T	DO223662	PRAD	ICGC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.V339G	DO218842	SKCA	ICGC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7532
p.L351R	SIDM00541	Colorectal Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.L351R	ACH-000926	Colon/Colorectal Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.L351R	HT55	large intestine	COSMIC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.L351F	SIDM00185	Melanoma	GDSC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.L351F	ACH-002152	Skin Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.L351F	LB2518-MEL	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.S340I	SIDM00681	Colorectal Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7341
p.S340I	SIDM01641	Non-Cancerous	GDSC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7341
p.S340I	ACH-002376	Non-Cancerous	CCLE	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7341
p.E350K	SIDM01059	Melanoma	GDSC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.E350K	ACH-000915	Skin Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.E350K	IPC-298	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.L331H	ACH-000127	Bladder Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.S345Y	ACH-001390	Breast Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for CCR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCR1

UniProt ID: P32246

Entrez ID: 1230

Protein name: C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCR1 in