DegronMD - P33993(MCM7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R225W	TCGA-A6-2686	COAD	TCGA	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.8634
p.R225W	DO7828	COAD	ICGC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.8634
p.D100N	TCGA-AP-A1DV	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5821
p.D100N	DO43186	UCEC	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5821
p.R114W	TCGA-AX-A2HD	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0556
p.R106Q	TCGA-AX-A2HD	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.R106Q	DO42608	UCEC	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.E90D	TCGA-BP-5187	KIRC	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0833
p.E90D	DO17633	KIRC	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0833
p.Q111L	TCGA-BR-8487	STAD	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1389
p.R112Q	TCGA-CD-A4MG	STAD	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112Q	DO48009	STAD	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112Q	ACH-001685	Lymphoma	CCLE	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.E110K	TCGA-CR-5248	HNSC	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1667
p.E110K	DO14694	HNSC	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1667
p.S113N	TCGA-D1-A103	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.5278
p.S113N	DO42312	UCEC	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.5278
p.E234K	TCGA-FR-A7U9	SKCM	TCGA	LQTRGSR	SCF_FBXL2	222:228	Mutation rewiring degron network	0.1667
p.E234K	DO48546	SKCM	ICGC	LQTRGSR	SCF_FBXL2	222:228	Mutation rewiring degron network	0.1667
p.V98G	TCGA-P5-A730	LGG	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.V98G	DO219830	LGG	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.R219W	TCGA-VQ-A8PP	STAD	TCGA	LQTRGSR	SCF_FBXL2	222:228	Mutation rewiring degron network	0.25
p.R219W	DO51774	STAD	ICGC	LQTRGSR	SCF_FBXL2	222:228	Mutation rewiring degron network	0.25
p.D97H	DO225343	BRCA	ICGC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.R620G	DO234213	ESAD	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0833
p.R611S	DO229015	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6316
p.R618S	DO229028	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1389
p.L607M	DO229041	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.711
p.S595N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.S595N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R611C	SIDM00217	Colorectal Carcinoma	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.719
p.R611C	ACH-000999	Colon/Colorectal Cancer	CCLE	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.719
p.R611C	SNU-1040	large intestine	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.719
p.R611H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.7133
p.R611H	ACH-001127	Leukemia	CCLE	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.7133
p.R611H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.7133
p.S227F	SIDM00213	Thyroid Gland Carcinoma	GDSC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.6871
p.S227F	FTC-133	thyroid	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.6871
p.K231N	SIDM00118	Colorectal Carcinoma	GDSC	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.K231N	ACH-001081	Colon/Colorectal Cancer	CCLE	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.K231N	HCC2998	large intestine	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.R112W	SIDM00980	Gastric Carcinoma	GDSC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112W	ACH-000948	Gastric Cancer	CCLE	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112W	23132-87	stomach	COSMIC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.Y102H	SIDM01608	Endometrial Carcinoma	GDSC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.7229
p.Y102H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.7229
p.G108R	LS-411N	large intestine	COSMIC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2222
p.R231Q	KURAMOCHI	ovary	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.R106C	TE-4	oesophagus	COSMIC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.R106C	KYAE-1	oesophagus	COSMIC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.V97I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.R225Q	NCI-H1417	lung	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.7329

Kaplan plot for MCM7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM7

UniProt ID: P33993

Entrez ID: 4176

Protein name: DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM7 in