DegronMD - P33993(MCM7)

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two ... View more >>

GO - Biological processes (BP): cell cycle [GO:0007049]; cell population proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to xenobiotic stimulus [GO:0071466]; DNA replication [GO:0006260]; DNA replication initiat... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]

GO - Cellular component (CC): chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytosol [GO:0005829]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
ARTLLAILR	DEG_APCC_DBOX_1	APC,CDC20,FZR1	DNA replication licensing factor MCM7	603:611	More..
LDVYIE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	DNA replication licensing factor MCM7	99:104	More..
LQTRGSR	SCF_FBXL2	FBXL2	DNA replication licensing factor MCM7	222:228	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R225W	TCGA-A6-2686	COAD	TCGA	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.8634
p.R225W	DO7828	COAD	ICGC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.8634
p.R225Q	NCI-H1417	lung	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.7329
p.Y102H	SIDM01608	Endometrial Carcinoma	GDSC	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.7229
p.Y102H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.7229
p.R611C	SIDM00217	Colorectal Carcinoma	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.719
p.R611C	ACH-000999	Colon/Colorectal Cancer	CCLE	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.719
p.R611C	SNU-1040	large intestine	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.719
p.R611H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.7133
p.R611H	ACH-001127	Leukemia	CCLE	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.7133
p.R611H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.7133
p.L607M	DO229041	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.711
p.K231N	SIDM00118	Colorectal Carcinoma	GDSC	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.K231N	ACH-001081	Colon/Colorectal Cancer	CCLE	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.K231N	HCC2998	large intestine	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.R231Q	KURAMOCHI	ovary	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation blocking ubiquitination signal	0.6944
p.S227F	SIDM00213	Thyroid Gland Carcinoma	GDSC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.6871
p.S227F	FTC-133	thyroid	COSMIC	LQTRGSR	SCF_FBXL2	222:228	Mutation altering degron motif	0.6871
p.R611S	DO229015	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6316
p.D100N	TCGA-AP-A1DV	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5821

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Kaplan plot for MCM7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM7

UniProt ID: P33993

Entrez ID: 4176

Protein name: DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM7 in