DegronMD - P34741(SDC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q94E	TCGA-06-2558	GBM	TCGA	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.K76N	TCGA-A5-A0G2	UCEC	TCGA	VETTT	DEG_SPOP_SBC_1	86:90	Mutation substituting flanking lysine	0.1667
p.A82D	TCGA-AP-A051	UCEC	TCGA	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.I77K	TCGA-B5-A3FA	UCEC	TCGA	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.S81R	TCGA-BR-6457	STAD	TCGA	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.Q94H	TCGA-BR-A4QL	STAD	TCGA	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.Y95C	DO219093	BLCA	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.M85T	DO219068	BLCA	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.D79N	DO1076	BRCA	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1389
p.E89K	DO3061	BRCA	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7022
p.E89K	DO8842	COAD	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7022
p.E89K	DO30050	OV	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7022
p.E89Q	DO15791	HNSC	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.6744
p.L78F	DO229489	LAML	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.V94L	DO229041	LICA	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.H77Q	DO26445	LUSC	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.S79C	DO219221	LUSC	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1389
p.L78V	DO228322	MALY	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.L78V	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.S79Y	DO37523	SKCM	ICGC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1389
p.T89M	SIDM02026	Colorectal Carcinoma	GDSC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7423
p.P98L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.P98L	LC-2-ad	lung	COSMIC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.I93T	SIDM01608	Endometrial Carcinoma	GDSC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.25
p.Q100P	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0556
p.D93H	ACH-000589	Lung Cancer	CCLE	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.25
p.D93H	NCI-H1437	lung	COSMIC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.25
p.L85V	ACH-001636	Lymphoma	CCLE	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.L85V	ACH-002300	Lymphoma	CCLE	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.L85V	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.D86H	NCI-H1437	lung	COSMIC	VETTT	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7688

Kaplan plot for SDC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SDC2

UniProt ID: P34741

Entrez ID: 6383

Protein name: Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SDC2 in