DegronMD - P40197(GP5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S488L	TCGA-24-2281	OV	TCGA	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7667
p.S488L	DO32459	OV	ICGC	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7667
p.R476L	TCGA-46-3768	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1111
p.R476L	DO26466	LUSC	ICGC	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1111
p.R481H	TCGA-DK-A1A7	BLCA	TCGA	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.25
p.R481H	DO483	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.25
p.P478L	TCGA-GF-A6C9	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.P478L	DO51254	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.P482L	TCGA-LH-A9QB	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.P482L	DO51266	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.P494S	TCGA-XK-AAIW	PRAD	TCGA	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.P494S	DO51407	PRAD	ICGC	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.P491L	DO220873	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons