MAGEA2; MAGEA2B
UniProt ID: P43356
Entrez ID: 266740
Protein name: Melanoma-associated antigen 2 (Cancer/testis antigen 1.2) (CT1.2) (MAGE-2 antigen)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activ...
FUNCTION: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269|PubMed:16847267, ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:22117195}.
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GO - Biological processes (BP):
cellular protein catabolic process [GO:0044257]; cellular senescence [GO:0090398]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquiti...
cellular protein catabolic process [GO:0044257]; cellular senescence [GO:0090398]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; signal transduction by p53 class mediator [GO:0072331]
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GO - Molecular function (MF):
DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; ubiquitin protein ligase binding [GO:0031625]...
DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; ubiquitin protein ligase binding [GO:0031625]
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GO - Cellular component (CC):
nucleus [GO:0005634]; PML body [GO:0016605]...
nucleus [GO:0005634]; PML body [GO:0016605]
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MAGEA2; MAGEA2B
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Kaplan plot for MAGEA2; MAGEA2B in
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*NOTE: the Kaplan plots were collected from OncoLnc