FUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:31267705, PubMed:17942928, PubMed:20864041). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRI...
FUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:31267705, PubMed:17942928, PubMed:20864041). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705}.
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GO - Biological processes (BP):
negative regulation of autophagy [GO:0010507]; negative regulation of transcription by RNA polymerase II [GO:0000122]...
negative regulation of autophagy [GO:0010507]; negative regulation of transcription by RNA polymerase II [GO:0000122]
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GO - Molecular function (MF):
histone deacetylase binding [GO:0042826]...
histone deacetylase binding [GO:0042826]
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GO - Cellular component (CC):
nucleus [GO:0005634]...
nucleus [GO:0005634]
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