DegronMD - P48553(TRAPPC10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1210M	TCGA-AP-A0LM	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1389
p.V1210M	TCGA-F4-6570	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1389
p.V1210M	DO10443	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1389
p.V1210M	DO43306	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1389
p.V1210M	ACH-001786	Colon/Colorectal Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1389
p.S1209N	TCGA-B0-5098	KIRC	TCGA	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation blocking phosphorylation signal	0.6111
p.S1209N	DO18938	KIRC	ICGC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation blocking phosphorylation signal	0.6111
p.D1200N	TCGA-CA-6718	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation altering degron motif	0.5821
p.D1200N	DO7801	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation altering degron motif	0.5821
p.G1195E	DO37827	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.2222
p.H1194N	DO229213	THCA	ICGC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1944
p.H1194P	ACH-000929	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1944
p.H1194P	NCI-H2110	lung	COSMIC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1944
p.S1206N	ACH-002198	Gastric Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation blocking phosphorylation signal	0.6944
p.S1206N	SCH	stomach	COSMIC	PDSSS	DEG_SPOP_SBC_1	1199:1203	Mutation blocking phosphorylation signal	0.6944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons