DegronMD - P48995(TRPC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E30V	TCGA-43-8118	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.E30V	DO45471	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.S17Y	TCGA-AC-A23H	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.712
p.S17Y	DO2401	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.712
p.S22F	TCGA-AJ-A3EL	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.S22F	TCGA-AJ-A3EL	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.S22F	TCGA-C5-A1MF	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.S22F	TCGA-C5-A1MF	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.S22F	DO6251	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.S22F	DO6251	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.S22F	DO41542	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.S22F	DO41542	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.A33V	TCGA-AJ-A5DW	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.A33V	TCGA-BR-8591	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.A33V	DO47973	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.A33V	DO50075	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.P23S	TCGA-C5-A1MF	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6752
p.P23S	DO6251	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6752
p.E30K	TCGA-CV-6961	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.E30K	DO14566	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.D10Y	TCGA-N7-A4Y8	UCS	TCGA	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.A33G	DO234183	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.M32I	DO223053	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.V37A	DO229275	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.A33S	DO229240	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.S17T	SIDM00672	Hepatocellular Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM01265	Plasma Cell Myeloma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00845	Burkitt's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM01090	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00855	Other Sarcomas	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00633	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00690	Head and Neck Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM01039	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00971	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00849	Kidney Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM01187	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00863	Burkitt's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00721	Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM00785	Acute Myeloid Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.S17T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6005
p.A14V	SIDM00845	Burkitt's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.5825
p.S12W	SIDM00498	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2778
p.S12W	SIDM01435	Hepatocellular Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2778
p.S12W	SIDM01442	Glioma	GDSC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2778
p.S12W	SNU-C5	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2778

Kaplan plot for TRPC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRPC1

UniProt ID: P48995

Entrez ID: 7220

Protein name: Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRPC1 in