DegronMD - P49760(CLK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E104D	TCGA-80-5611	LUAD	TCGA	DYR	CBL_MET	94:96	Mutation rewiring degron network	0.1111
p.E104D	DO23822	LUAD	ICGC	DYR	CBL_MET	94:96	Mutation rewiring degron network	0.1111
p.Y95C	TCGA-A6-5659	COAD	TCGA	DYR	CBL_MET	94:96	Mutation altering degron motif	0.8198
p.Y95C	DO9860	COAD	ICGC	DYR	CBL_MET	94:96	Mutation altering degron motif	0.8198
p.D94G	TCGA-DT-5265	READ	TCGA	DYR	CBL_MET	94:96	Mutation altering degron motif	0.7198
p.D94G	DO36499	READ	ICGC	DYR	CBL_MET	94:96	Mutation altering degron motif	0.7198
p.S98F	TCGA-EE-A2GS	SKCM	TCGA	DYR	CBL_MET	94:96	Mutation blocking phosphorylation signal	0.7222
p.S98F	DO37465	SKCM	ICGC	DYR	CBL_MET	94:96	Mutation blocking phosphorylation signal	0.7222
p.G87V	TCGA-EE-A3J7	SKCM	TCGA	DYR	CBL_MET	94:96	Mutation rewiring degron network	0.1389
p.G87V	DO48770	SKCM	ICGC	DYR	CBL_MET	94:96	Mutation rewiring degron network	0.1389
p.R96L	TCGA-J2-A4AG	LUAD	TCGA	DYR	CBL_MET	94:96	Mutation altering degron motif	0.8428
p.R96L	DO23714	LUAD	ICGC	DYR	CBL_MET	94:96	Mutation altering degron motif	0.8428
p.D92N	TCGA-P3-A5QF	HNSC	TCGA	DYR	CBL_MET	94:96	Mutation rewiring degron network	0.2778
p.D92N	DO44439	HNSC	ICGC	DYR	CBL_MET	94:96	Mutation rewiring degron network	0.2778
p.R103W	DO222874	COCA	ICGC	DYR	CBL_MET	94:96	Mutation rewiring degron network	0.1389
p.D94H	DO233944	GACA	ICGC	DYR	CBL_MET	94:96	Mutation altering degron motif	0.7688

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons