DegronMD - P49796(RGS3)

FUNCTION: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}.

GO - Biological processes (BP): G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]

GO - Molecular function (MF): GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]

GO - Cellular component (CC): cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R550L	DO218998	BLCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.8428
p.R550L	OV-90	ovary	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.8428
p.R279H	DO230323	COCA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.8244
p.R279H	DO41644	UCEC	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.8244
p.P273H	DO22333	LGG	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7694
p.M553I	DO229459	SKCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7618
p.A279S	DO229026	LICA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7588
p.Q557H	DO26536	LUSC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7582
p.P275L	Hs939-T	skin	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7582
p.G274R	DO38795	STAD	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7568
p.R274W	TCGA-AA-3864	COAD	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7523
p.V545M	MZ7-mel	skin	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation blocking phosphorylation signal	0.75
p.T549M	HCT-15	large intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7423
p.Q557R	DO4257	BRCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7329
p.R550Q	DO43154	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7329
p.D554Y	DO228985	LICA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7325
p.V245M	LNCaP-Clone-FGC	prostate	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation altering degron motif	0.7208
p.A547T	TCGA-CG-5723	STAD	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7139
p.T247I	TCGA-AX-A2HD	UCEC	TCGA	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation altering degron motif	0.7078
p.T552I	DO8858	COAD	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7078

Showing 1 to 20 of 78 entries

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No resistance data available for this Degron.

Kaplan plot for RGS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS3

UniProt ID: P49796

Entrez ID: 5998

Protein name: Regulator of G-protein signaling 3 (RGP3) (RGS3)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for RGS3 in