DegronMD - P49796(RGS3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A566V	TCGA-06-5416	GBM	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.0833
p.E261D	TCGA-38-4631	LUAD	TCGA	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.0556
p.R567Q	TCGA-38-4631	LUAD	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.0556
p.M286I	TCGA-63-A5MW	LUSC	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1667
p.R274W	TCGA-AA-3864	COAD	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7523
p.T247I	TCGA-AX-A2HD	UCEC	TCGA	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation altering degron motif	0.7078
p.P282Q	TCGA-BF-A1Q0	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.2778
p.A547T	TCGA-CG-5723	STAD	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7139
p.G541C	TCGA-D3-A3CE	SKCM	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.1944
p.P554H	TCGA-DU-7294	LGG	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.6583
p.G241R	TCGA-EE-A20C	SKCM	TCGA	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.2222
p.G241R	DO222775	MELA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.2222
p.G241R	DO47665	SKCM	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.2222
p.G290W	TCGA-EE-A2GH	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.0556
p.P282S	TCGA-EE-A3AC	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.2778
p.R275Q	TCGA-F5-6814	READ	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.6218
p.G288E	TCGA-W3-AA1V	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1111
p.R550L	DO218998	BLCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.8428
p.R550L	OV-90	ovary	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.8428
p.Q557R	DO4257	BRCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7329
p.R236C	DO9314	COAD	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.0833
p.T552I	DO8858	COAD	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7078
p.R279H	DO230323	COCA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.8244
p.R279H	DO41644	UCEC	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.8244
p.G240D	DO230346	COCA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.1944
p.A254T	DO44440	HNSC	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.25
p.H241Q	DO223947	KIRP	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.2222
p.P273H	DO22333	LGG	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7694
p.R559C	DO22237	LGG	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.2778
p.M263I	DO228508	LICA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.0833
p.D554Y	DO228985	LICA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7325
p.A279S	DO229026	LICA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7588
p.R237S	DO229035	LICA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.1111
p.C285F	DO229037	LICA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1944
p.V237L	DO229037	LICA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.1111
p.C242Y	DO52185	LIHC	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.25
p.P252L	DO24596	LUAD	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.3056
p.Q557H	DO26536	LUSC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7582
p.K546N	DO51511	PACA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.6918
p.M553I	DO229459	SKCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7618
p.P265S	DO37567	SKCM	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1389
p.Q266K	DO37896	SKCM	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1667
p.G562W	DO37916	SKCM	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.1944
p.G562W	RKO	large intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.1944
p.G274R	DO38795	STAD	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7568
p.R260C	DO38186	STAD	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.0833
p.R253H	DO229211	THCA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.2778
p.K558N	DO43186	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.3056
p.R550Q	DO43154	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7329
p.R270W	DO43891	UCEC	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.2778
p.D554N	DO43755	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.6932
p.V550I	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.5965
p.V550I	SIDM00257	Neuroblastoma	GDSC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.5965
p.V550I	ACH-000953	Leukemia	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.5965
p.V550I	ACH-002280	Neuroblastoma	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.5965
p.V550I	NB13	autonomic ganglia	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.5965
p.V550I	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.5965
p.G289S	SIDM01763	Rhabdomyosarcoma	GDSC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.0833
p.G541D	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.1944
p.S244F	ACH-002396	Bone Cancer	CCLE	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.3056
p.S244F	Sarc9371	bone	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.3056
p.V269I	NB13	autonomic ganglia	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.25
p.V269I	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.25
p.K237T	HT-115	large intestine	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.1111
p.V245M	LNCaP-Clone-FGC	prostate	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation altering degron motif	0.7208
p.R270L	OV-90	ovary	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.2778
p.P275L	Hs939-T	skin	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7582
p.E253D	SW948	large intestine	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	245:251	Mutation rewiring degron network	0.2778
p.V275A	GP5d	large intestine	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.6936
p.L558P	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.3056
p.A567V	HEC-1	endometrium	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.0556
p.R262H	SiHa	cervix	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.0556
p.T269M	HCT-15	large intestine	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.25
p.G282W	RKO	large intestine	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.2778
p.P565T	HCT-15	large intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation rewiring degron network	0.1111
p.V283M	MZ7-mel	skin	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.25
p.V545M	MZ7-mel	skin	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation blocking phosphorylation signal	0.75
p.T549M	HCT-15	large intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	546:557	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS3

UniProt ID: P49796

Entrez ID: 5998

Protein name: Regulator of G-protein signaling 3 (RGP3) (RGS3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RGS3 in