DegronMD - P50402(EMD)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M191I	TCGA-A5-A0G1	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2222
p.M191I	TCGA-E6-A1LX	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2222
p.M191I	DO41020	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2222
p.M191I	DO42472	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2222
p.L64F	TCGA-BA-5152	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation rewiring degron network	0.0556
p.L64F	DO14393	HNSC	ICGC	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation rewiring degron network	0.0556
p.S58C	TCGA-C5-A1M6	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation blocking phosphorylation signal	0.6667
p.S58C	TCGA-K4-A5RH	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation blocking phosphorylation signal	0.6667
p.S58C	DO219028	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation blocking phosphorylation signal	0.6667
p.S58C	DO48985	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation blocking phosphorylation signal	0.6667
p.S185F	TCGA-EE-A181	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7982
p.S185F	DO37444	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7982
p.R174S	TCGA-EE-A29G	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0833
p.R174S	DO47303	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0833
p.P51S	TCGA-EE-A2MP	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.5641
p.P51S	DO37818	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.5641
p.Y181N	TCGA-ER-A19D	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation blocking phosphorylation signal	0.7222
p.Y181N	DO37750	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation blocking phosphorylation signal	0.7222
p.S53L	TCGA-GN-A262	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.8778
p.S53L	DO37515	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.8778
p.S180T	DO231284	PACA	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation blocking phosphorylation signal	0.6944
p.S175C	DO229421	PRAD	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation blocking phosphorylation signal	0.5556
p.F61L	DO36556	READ	ICGC	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation rewiring degron network	0.1389
p.S52R	HCC1143	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.8538
p.A180D	TUR	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation blocking phosphorylation signal	0.6944
p.R186C	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.8301

Kaplan plot for EMD in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EMD

UniProt ID: P50402

Entrez ID: 2010

Protein name: Emerin

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EMD in