DegronMD - P51168(SCNN1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P613T	TCGA-66-2759	LUSC	TCGA	PPNY	ITCH	617:620	Mutation rewiring degron network	0.2222
p.A612T	DO223588	BLCA	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.1944
p.R608W	DO223383	CLLE	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.0833
p.R610W	DO227996	COCA	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.1389
p.P621H	DO233766	GACA	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.3056
p.R610Q	DO13863	GBM	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.1389
p.A617S	DO49670	LIAD	ICGC	PPNY	ITCH	617:620	Mutation altering degron motif	0.7588
p.A617S	DO22812	LICA	ICGC	PPNY	ITCH	617:620	Mutation altering degron motif	0.7588
p.V627L	DO228974	LICA	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.1389
p.R608L	DO229006	LICA	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.0833
p.P619Q	DO218861	SKCA	ICGC	PPNY	ITCH	617:620	Mutation altering degron motif	0.7035
p.E625K	DO219456	SKCM	ICGC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.1944
p.R624H	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.2222
p.R624H	SIDM00238	Ovarian Carcinoma	GDSC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.2222
p.R624H	BEN	lung	COSMIC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.2222
p.R624H	OVK-18	ovary	COSMIC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.2222
p.Q608H	SIDM00511	Small Cell Lung Carcinoma	GDSC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.0833
p.Q608H	COR-L279	lung	COSMIC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.0833
p.P617T	SIDM00901	Endometrial Carcinoma	GDSC	PPNY	ITCH	617:620	Mutation altering degron motif	0.7031
p.G610V	ACH-001793	Liposarcoma	CCLE	PPNY	ITCH	617:620	Mutation rewiring degron network	0.1389
p.T622I	ES-2	ovary	COSMIC	PPNY	ITCH	617:620	Mutation rewiring degron network	0.2778

Kaplan plot for SCNN1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCNN1B

UniProt ID: P51168

Entrez ID: 6338

Protein name: Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCNN1B in