DegronMD - P51170(SCNN1G)

SCNN1G

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R631C	TCGA-AO-A128	BRCA	TCGA	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.R631C	TCGA-B5-A3FC	UCEC	TCGA	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.R631C	DO5326	BRCA	ICGC	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.R631C	DO52751	CMDI	ICGC	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.R631C	DO41871	UCEC	ICGC	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.Y627C	TCGA-AP-A0LM	UCEC	TCGA	PPKY	ITCH	624:627	Mutation altering degron motif	0.7087
p.Y627C	DO43306	UCEC	ICGC	PPKY	ITCH	624:627	Mutation altering degron motif	0.7087
p.P625S	TCGA-DA-A1I7	SKCM	TCGA	PPKY	ITCH	624:627	Mutation altering degron motif	0.6752
p.P625S	DO37951	SKCM	ICGC	PPKY	ITCH	624:627	Mutation altering degron motif	0.6752
p.R631H	TCGA-DF-A2KU	UCEC	TCGA	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.R631H	DO223286	UCEC	ICGC	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.T629P	DO222798	COCA	ICGC	PPKY	ITCH	624:627	Mutation blocking phosphorylation signal	0.7222
p.R631L	DO229029	LICA	ICGC	PPKY	ITCH	624:627	Mutation rewiring degron network	0.2222
p.T629I	DO229453	SKCA	ICGC	PPKY	ITCH	624:627	Mutation blocking phosphorylation signal	0.7222
p.P625L	SIDM01175	Other Sarcomas	GDSC	PPKY	ITCH	624:627	Mutation altering degron motif	0.7582
p.P625L	ACH-002309	Sarcoma	CCLE	PPKY	ITCH	624:627	Mutation altering degron motif	0.7582
p.P625L	SW684	soft tissue	COSMIC	PPKY	ITCH	624:627	Mutation altering degron motif	0.7582

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*NOTE: the Kaplan plots were collected from OncoLnc