DegronMD - P51575(P2RX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L392R	TCGA-24-1463	OV	TCGA	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.L392R	DO30690	OV	ICGC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.A384T	TCGA-AP-A1DV	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7139
p.A384T	TCGA-FI-A2D5	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7139
p.A384T	DO43186	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7139
p.A384T	DO41331	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7139
p.Q393H	TCGA-EE-A2MG	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.Q393H	DO37421	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.D382G	TCGA-FI-A2D5	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2778
p.D382G	DO41331	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2778
p.D382E	DO229009	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2778
p.R381C	DO229259	THCA	ICGC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.25
p.R381C	ACH-001745	Sarcoma	CCLE	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.25
p.A379V	SIDM00683	Prostate Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.A379V	LNCaP-Clone-FGC	prostate	COSMIC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.R381H	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.25
p.R381H	SIDM00654	Small Cell Lung Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.25
p.M396V	SIDM00056	Thyroid Gland Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1111
p.M396V	SIDM00720	Mesothelioma	GDSC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1111
p.M396V	SIDM01525	Acute Myeloid Leukemia	GDSC	AATSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1111

Kaplan plot for P2RX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

P2RX1

UniProt ID: P51575

Entrez ID: 5023

Protein name: P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for P2RX1 in