DegronMD - P51813(BMX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S212R	TCGA-13-1488	OV	TCGA	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2778
p.S212R	DO29438	OV	ICGC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2778
p.A184V	TCGA-AP-A059	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.5825
p.A184V	DO41361	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.5825
p.Q205K	TCGA-B0-4810	KIRC	TCGA	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.3056
p.Q205K	DO17643	KIRC	ICGC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.3056
p.N201H	TCGA-B5-A0JY	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1944
p.N201H	DO43041	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1944
p.K199N	TCGA-CA-6717	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation substituting flanking lysine	0.25
p.K199N	DO8264	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation substituting flanking lysine	0.25
p.Y216H	TCGA-CK-6751	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation blocking phosphorylation signal	0.6111
p.Y216H	DO10340	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation blocking phosphorylation signal	0.6111
p.P174S	TCGA-D1-A176	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.P174S	DO43947	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.Q193P	TCGA-D8-A27M	BRCA	TCGA	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.Q193P	DO1380	BRCA	ICGC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.A176T	TCGA-EE-A3J5	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.A176T	DO47331	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.P206A	TCGA-ER-A2NE	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.6392
p.P206A	DO48663	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.6392
p.Q193K	TCGA-GN-A268	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.Q193K	DO37477	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.K181R	DO223060	ESCA	ICGC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation substituting flanking lysine	0.3611
p.A192S	DO229006	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2222
p.K199T	DO229590	PRAD	ICGC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation substituting flanking lysine	0.25
p.G203D	SIDM01119	Other Solid Cancers	GDSC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.25
p.G203D	ACH-000775	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.25
p.G203D	NCI-H727	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.25
p.P185R	SIDM01107	Melanoma	GDSC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6401
p.P185R	ACH-000465	Skin Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6401
p.P185R	SK-MEL-1	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6401
p.S187P	SIDM01084	Osteosarcoma	GDSC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6752
p.S187P	Saos-2	bone	COSMIC	APSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6752

Kaplan plot for BMX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMX

UniProt ID: P51813

Entrez ID: 660

Protein name: Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMX in