DegronMD - P51841(GUCY2F)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V774A	TCGA-A5-A1OF	UCEC	TCGA	PPVY	ITCH	768:771	Mutation rewiring degron network	0.25
p.V774A	DO42568	UCEC	ICGC	PPVY	ITCH	768:771	Mutation rewiring degron network	0.25
p.N762H	TCGA-AA-3511	COAD	TCGA	PPVY	ITCH	768:771	Mutation rewiring degron network	0.1667
p.N762H	DO7804	COAD	ICGC	PPVY	ITCH	768:771	Mutation rewiring degron network	0.1667
p.P768H	TCGA-AP-A1E0	UCEC	TCGA	PPVY	ITCH	768:771	Mutation altering degron motif	0.7694
p.P768H	DO43154	UCEC	ICGC	PPVY	ITCH	768:771	Mutation altering degron motif	0.7694
p.P781H	TCGA-B5-A1MX	UCEC	TCGA	PPVY	ITCH	768:771	Mutation rewiring degron network	0.0556
p.P781H	DO41999	UCEC	ICGC	PPVY	ITCH	768:771	Mutation rewiring degron network	0.0556
p.P769L	TCGA-D7-6526	STAD	TCGA	PPVY	ITCH	768:771	Mutation altering degron motif	0.7582
p.P769L	DO38803	STAD	ICGC	PPVY	ITCH	768:771	Mutation altering degron motif	0.7582
p.P768S	TCGA-EE-A2MS	SKCM	TCGA	PPVY	ITCH	768:771	Mutation altering degron motif	0.6752
p.P768S	DO37567	SKCM	ICGC	PPVY	ITCH	768:771	Mutation altering degron motif	0.6752
p.E778K	DO222875	MELA	ICGC	PPVY	ITCH	768:771	Mutation rewiring degron network	0.1389
p.P769S	SIDM01175	Other Sarcomas	GDSC	PPVY	ITCH	768:771	Mutation altering degron motif	0.6752
p.P769S	ACH-002309	Sarcoma	CCLE	PPVY	ITCH	768:771	Mutation altering degron motif	0.6752
p.P769S	SW684	soft tissue	COSMIC	PPVY	ITCH	768:771	Mutation altering degron motif	0.6752
p.V775A	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPVY	ITCH	768:771	Mutation rewiring degron network	0.2222
p.V775A	ACH-002214	Lymphoma	CCLE	PPVY	ITCH	768:771	Mutation rewiring degron network	0.2222
p.V775A	BC-1	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	768:771	Mutation rewiring degron network	0.2222
p.I760M	IST-MEL1	skin	COSMIC	PPVY	ITCH	768:771	Mutation rewiring degron network	0.1111

Kaplan plot for GUCY2F in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GUCY2F

UniProt ID: P51841

Entrez ID: 2986

Protein name: Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for GUCY2F in