DegronMD - P51854(TKTL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V285F	TCGA-36-2538	OV	TCGA	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.3056
p.I272V	TCGA-BR-8361	STAD	TCGA	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.0556
p.R292W	TCGA-BT-A20V	BLCA	TCGA	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1111
p.S279Y	TCGA-EE-A17Z	SKCM	TCGA	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.25
p.Q285R	DO219031	BLCA	ICGC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.3056
p.V290M	DO222739	ESCA	ICGC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1667
p.V290M	DO47769	STAD	ICGC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1667
p.R276H	DO223720	LUSC	ICGC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1667
p.E272A	DO50142	STAD	ICGC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.0556
p.L292M	DO43306	UCEC	ICGC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1111
p.S289N	DO43891	UCEC	ICGC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1944
p.R292Q	SIDM00080	Melanoma	GDSC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1111
p.R292Q	ACH-000730	Skin Cancer	CCLE	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1111
p.R292Q	SK-MEL-5	skin	COSMIC	DYR	CBL_MET	282:284	Mutation rewiring degron network	0.1111
p.R284K	SIDM01483	Melanoma	GDSC	DYR	CBL_MET	282:284	Mutation altering degron motif	0.7237
p.R284K	ACH-000582	Skin Cancer	CCLE	DYR	CBL_MET	282:284	Mutation altering degron motif	0.7237
p.R284K	COLO-741	large intestine	COSMIC	DYR	CBL_MET	282:284	Mutation altering degron motif	0.7237
p.Y283C	ACH-001991	Primary	CCLE	DYR	CBL_MET	282:284	Mutation altering degron motif	0.7087
p.E284A	DU-4475	breast	COSMIC	DYR	CBL_MET	282:284	Mutation altering degron motif	0.7701

Kaplan plot for TKTL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TKTL1

UniProt ID: P51854

Entrez ID: 8277

Protein name: Transketolase-like protein 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TKTL1 in