DegronMD - P52737(ZNF136)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R440I	TCGA-AZ-4315	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1667
p.R440I	DO8842	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1667
p.R436Q	TCGA-B5-A1MR	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.R436Q	DO41758	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.G444V	TCGA-DK-A6B6	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0556
p.G444V	DO48576	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0556
p.S431Y	TCGA-ND-A4WC	UCS	TCGA	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.6009
p.K427T	DO228239	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation substituting flanking lysine	0.3611
p.G426C	DO229019	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.I435F	DO50843	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.3056
p.A428S	DO232224	PBCA	ICGC	VSSTS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons