DegronMD - P53999(SUB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S4L	TCGA-29-1775	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6667
p.S4L	DO30870	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6667
p.K38N	TCGA-A5-A0G2	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation substituting flanking lysine	0.1667
p.K38N	DO41235	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation substituting flanking lysine	0.1667
p.S57N	TCGA-A8-A09Z	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation blocking phosphorylation signal	0.6389
p.S57N	DO5521	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation blocking phosphorylation signal	0.6389
p.K3T	TCGA-AP-A0LM	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6389
p.K3T	DO43306	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6389
p.S46L	TCGA-E6-A1LX	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation rewiring degron network	0.2778
p.S46L	DO41020	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation rewiring degron network	0.2778
p.S46L	SIDM01611	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation rewiring degron network	0.2778
p.S46L	ACH-000996	Endometrial/Uterine Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation rewiring degron network	0.2778
p.Q40H	DO8730	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation rewiring degron network	0.1111
p.S57I	DO229026	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	48:52	Mutation blocking phosphorylation signal	0.6389
p.S12C	SIDM00927	Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.8652
p.S12C	ACH-000871	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.8652
p.S12C	NCI-H510A	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.8652
p.K3E	SIDM01588	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6389
p.K3E	ACH-000993	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for SUB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUB1

UniProt ID: P53999

Entrez ID: 10923

Protein name: Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUB1 in