DegronMD - P55055(NR1H2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P24T	TCGA-55-6980	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.5919
p.P24T	DO25518	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.5919
p.A23T	TCGA-A6-3809	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.A23T	TCGA-DU-6392	LGG	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.A23T	DO44090	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.A23T	DO8722	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.A23T	DO222737	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.A23T	DO22237	LGG	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.A23T	SIDM02015	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.P19T	TCGA-D3-A1Q3	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.P19T	DO47509	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.P37S	TCGA-DA-A95Z	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.P37S	DO219481	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.E32K	TCGA-DK-A2I1	BLCA	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.E32K	DO444	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.S8F	TCGA-EE-A17X	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.9093
p.S8F	DO37931	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.9093
p.K31N	TCGA-EO-A22R	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation substituting flanking lysine	0.3333
p.K31N	DO42713	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation substituting flanking lysine	0.3333
p.P35S	TCGA-FS-A1ZF	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.P35S	DO38039	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.T5S	DO227974	COCA	ICGC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.6005
p.L13P	DO233941	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.L13P	DO233941	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.A8T	DO222702	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7139
p.P28A	DO46358	OV	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.R15H	DO38663	STAD	ICGC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.R15H	DO38663	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.A32T	DO41871	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.G22D	SIDM01298	Esophageal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.P24L	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6471
p.P24L	ACH-000226	Lymphoma	CCLE	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6471
p.P24L	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6471
p.S2F	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.S2F	SIDM00041	Gastric Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.S2F	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.S2F	SIDM01752	Pancreatic Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.S26Y	SIDM00277	Acute Myeloid Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.712
p.S26Y	ACH-000198	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.712
p.S26Y	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.712
p.P12R	SIDM00101	Mesothelioma	GDSC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2222
p.P12R	ACH-002126	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2222
p.P12R	H2591	pleura	COSMIC	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2222
p.S8Y	ACH-001568	Skin Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.8231

Kaplan plot for NR1H2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NR1H2

UniProt ID: P55055

Entrez ID: 7376

Protein name: Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NR1H2 in