DegronMD - P55316(FOXG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q446K	TCGA-17-Z031	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2222
p.L451Q	TCGA-17-Z031	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0833
p.P452L	TCGA-3A-A9IV	PAAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.P452L	DO218959	PAAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.M434L	TCGA-56-8307	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2222
p.M434L	DO219139	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2222
p.S449L	TCGA-62-8394	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	TCGA-CV-7414	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	TCGA-ZF-A9R7	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	DO219064	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	DO15631	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	DO45382	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	SIDM00672	Hepatocellular Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	ACH-001521	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.S449L	Hep_3B2_1-7	NS	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1389
p.R437S	TCGA-78-7155	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.3056
p.R437S	DO23590	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.3056
p.P445T	TCGA-78-8640	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.P445T	DO45340	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.A439V	TCGA-AA-3492	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	TCGA-B5-A3FC	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	DO8224	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	DO41871	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	SIDM00449	B-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	ACH-000922	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	ACH-000953	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A439V	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.S444L	TCGA-AJ-A3EL	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2778
p.S444L	TCGA-AX-A2HD	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2778
p.S444L	DO41542	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2778
p.S444L	DO42608	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.2778
p.S428L	TCGA-AX-A0J0	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.S428L	TCGA-EO-A3B0	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.S428L	DO219773	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.S428L	DO41133	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.S428L	SIDM00193	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.S428L	ACH-000991	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.S428L	SNU-81	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.P445S	TCGA-D1-A177	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.P445S	DO42528	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.A447P	TCGA-FI-A2F4	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1944
p.A447P	DO43434	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1944
p.A438V	TCGA-XK-AAIW	PRAD	TCGA	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.A438V	DO51407	PRAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.5825
p.P445L	DO234401	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.T443M	DO229050	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.3056
p.T443M	SIDM00602	Gastric Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.3056
p.T443M	ACH-000919	Gastric Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.3056
p.T443M	IM-95	stomach	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.3056
p.S441F	DO224544	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7982
p.S441F	DO231014	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7982
p.P452T	DO229071	PRAD	ICGC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.0556
p.A439S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.6477
p.A439S	ACH-000840	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.6477
p.A439S	HCC-366	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.6477
p.S433T	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1944
p.S433T	ACH-000914	Lymphoma	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1944
p.S433T	HT	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1944
p.S440F	SIDM00080	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7982
p.S440F	ACH-000730	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7982
p.S440F	SK-MEL-5	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7982
p.S430T	SIDM00845	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	SIDM00461	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	ACH-000786	Lymphoma	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	ACH-000981	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	ACH-000992	Head and Neck Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	ACH-001067	Brain Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	DND-41	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	Daudi	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.S430T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1111
p.P448A	SIDM01133	Other Solid Cancers	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1667
p.P448A	ACH-002177	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1667
p.P448A	NCI-H835	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1667
p.A439E	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.659
p.A439E	ACH-000852	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.659
p.A439E	NCI-H1435	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.659

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXG1

UniProt ID: P55316

Entrez ID: 2290

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXG1 in