DegronMD - P57082(TBX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R368C	TCGA-21-1079	LUSC	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2778
p.R368C	TCGA-EE-A181	SKCM	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2778
p.R368C	ACH-002174	Lung Cancer	CCLE	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2778
p.R368C	NCI-H720	lung	COSMIC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2778
p.P380H	TCGA-37-3792	LUSC	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.D374Y	TCGA-86-8073	LUAD	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.3056
p.R368H	TCGA-95-7567	LUAD	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2778
p.P371T	TCGA-AA-3877	COAD	TCGA	PPPY	ITCH	370:373	Mutation altering degron motif	0.7031
p.Q376K	TCGA-AD-6889	COAD	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.25
p.D374N	TCGA-AL-3467	KIRP	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.3056
p.M377L	TCGA-BG-A2L7	UCEC	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2222
p.P372S	TCGA-FR-A8YE	SKCM	TCGA	PPPY	ITCH	370:373	Mutation altering degron motif	0.5641
p.H365Y	TCGA-G2-A3VY	BLCA	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1944
p.G362E	TCGA-WE-AAA3	SKCM	TCGA	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1111
p.H366Y	DO590	BLCA	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2222
p.P372T	DO7855	COAD	ICGC	PPPY	ITCH	370:373	Mutation altering degron motif	0.5919
p.P372T	DO233709	GACA	ICGC	PPPY	ITCH	370:373	Mutation altering degron motif	0.5919
p.Q377K	DO8463	COAD	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2222
p.R369H	DO25564	LUAD	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.3056
p.D375Y	DO23624	LUAD	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.2778
p.R369C	DO26846	LUSC	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.3056
p.R369C	DO37444	SKCM	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.3056
p.R369C	SIDM01120	Other Solid Cancers	GDSC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.3056
p.R369C	NCI-H720	lung	COSMIC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.3056
p.P381H	DO27192	LUSC	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1111
p.D365N	DO220897	MELA	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1944
p.P373S	DO50303	SKCM	ICGC	PPPY	ITCH	370:373	Mutation altering degron motif	0.6752
p.G363E	DO51295	SKCM	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.M378L	DO42344	UCEC	ICGC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1944
p.P381S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1111
p.P381S	COLO-680N	oesophagus	COSMIC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1111
p.S380N	SIDM00228	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.P380S	ACH-000717	Esophageal Cancer	CCLE	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.P380S	COLO-680N	oesophagus	COSMIC	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.S379N	ACH-000897	Thyroid Cancer	CCLE	PPPY	ITCH	370:373	Mutation rewiring degron network	0.1667

Kaplan plot for TBX4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBX4

UniProt ID: P57082

Entrez ID: 9496

Protein name: T-box transcription factor TBX4 (T-box protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBX4 in