DegronMD - P59827(BPIFB4)

FUNCTION: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). {ECO:0000250}.

GO - Biological processes (BP):

GO - Molecular function (MF): lipid binding [GO:0008289]

GO - Cellular component (CC): actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular region [GO:0005576]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P72L	TCGA-60-2721	LUSC	TCGA	PPVY	ITCH	72:75	Mutation altering degron motif	0.7582
p.P72L	DO26447	LUSC	ICGC	PPVY	ITCH	72:75	Mutation altering degron motif	0.7582
p.P72S	TCGA-EE-A3JE	SKCM	TCGA	PPVY	ITCH	72:75	Mutation altering degron motif	0.6752
p.P72S	DO48766	SKCM	ICGC	PPVY	ITCH	72:75	Mutation altering degron motif	0.6752
p.T76A	SIDM01951	Colorectal Carcinoma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.3056
p.P71S	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.3056
p.P71S	SIDM00087	Plasma Cell Myeloma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.3056
p.P71S	SIDM00954	Breast Carcinoma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.3056
p.P71S	SIDM00628	Breast Carcinoma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.3056
p.R69P	DO229005	COCA	ICGC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.25
p.R69P	DO230550	LUSC	ICGC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.25
p.G78V	DO229028	LICA	ICGC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.25
p.V68F	DO229029	LICA	ICGC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.2222
p.H67N	TCGA-2W-A8YY	CESC	TCGA	PPVY	ITCH	72:75	Mutation rewiring degron network	0.1944
p.H67N	DO223732	CESC	ICGC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.1944
p.L81F	DO228947	LICA	ICGC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.1667
p.L81F	DO229047	LICA	ICGC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.1667
p.L81F	SIDM01197	Colorectal Carcinoma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.1667
p.L81F	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.1667
p.L81F	SIDM01145	Gastric Carcinoma	GDSC	PPVY	ITCH	72:75	Mutation rewiring degron network	0.1667

Showing 1 to 20 of 34 entries

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Kaplan plot for BPIFB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BPIFB4

UniProt ID: P59827

Entrez ID: 149954

Protein name: BPI fold-containing family B member 4 (Ligand-binding protein RY2G5) (Long palate, lung and nasal epithelium carcinoma-associated protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BPIFB4 in