DegronMD - P61296(HAND2)

GO - Biological processes (BP): adult heart development [GO:0007512]; angiogenesis [GO:0001525]; apoptotic process involved in heart morphogenesis [GO:0003278]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cardiac right ventricle formation [GO:0003219]; cartilage morphogenesis [GO:0060536]; cell proliferation involved in outflow tract morphogenesis [GO:0061325]; cellular response to organic cyclic compound [GO:0071407]; cellular response to retinoic acid [GO:0071300]; coronary artery morphogenesis [GO:0060982]; developmental process [GO:0032502]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; mesenchymal cell proliferation [GO:0010463]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; noradrenergic neuron differentiation [GO:0003357]; odontogenesis of dentin-containing tooth [GO:0042475]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis [GO:2000764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process [GO:2000763]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; primary palate development [GO:1903929]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of tissue remodeling [GO:0034103]; regulation of transcription by RNA polymerase II [GO:0006357]; suckling behavior [GO:0001967]; sympathetic nervous system development [GO:0048485]; thymus development [GO:0048538]; tongue development [GO:0043586]; visceral serous pericardium development [GO:0061032] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G45C	TCGA-18-5592	LUSC	TCGA	PPDY	ITCH	55:58	Mutation rewiring degron network	0.0556
p.G45C	DO26432	LUSC	ICGC	PPDY	ITCH	55:58	Mutation rewiring degron network	0.0556
p.P55L	TCGA-EE-A29R	SKCM	TCGA	PPDY	ITCH	55:58	Mutation altering degron motif	0.7582
p.P55L	DO37448	SKCM	ICGC	PPDY	ITCH	55:58	Mutation altering degron motif	0.7582
p.S63F	TCGA-EE-A2MM	SKCM	TCGA	PPDY	ITCH	55:58	Mutation rewiring degron network	0.1944
p.S63F	DO37770	SKCM	ICGC	PPDY	ITCH	55:58	Mutation rewiring degron network	0.1944
p.H50N	TCGA-NK-A5CR	LUSC	TCGA	PPDY	ITCH	55:58	Mutation rewiring degron network	0.1944
p.H50N	DO219207	LUSC	ICGC	PPDY	ITCH	55:58	Mutation rewiring degron network	0.1944
p.P51H	DO229035	LICA	ICGC	PPDY	ITCH	55:58	Mutation rewiring degron network	0.2222
p.S54T	DO233296	NACA	ICGC	PPDY	ITCH	55:58	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HAND2

UniProt ID: P61296

Entrez ID: 9464

Protein name: Heart- and neural crest derivatives-expressed protein 2 (Class A basic helix-loop-helix protein 26) (bHLHa26) (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HAND2 in