DegronMD - P62333(PSMC6)

PSMC6

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R10T	TCGA-4Z-AA7W	BLCA	TCGA	DYR	CBL_MET	11:13	Mutation rewiring degron network	0.3056
p.R10T	DO218984	BLCA	ICGC	DYR	CBL_MET	11:13	Mutation rewiring degron network	0.3056
p.E9K	TCGA-E2-A10C	BRCA	TCGA	DYR	CBL_MET	11:13	Mutation rewiring degron network	0.2778
p.E9K	DO1334	BRCA	ICGC	DYR	CBL_MET	11:13	Mutation rewiring degron network	0.2778
p.I3V	DO23486	LINC	ICGC	DYR	CBL_MET	11:13	Mutation rewiring degron network	0.1111
p.A2V	SIDM00924	Other Solid Cancers	GDSC	DYR	CBL_MET	11:13	Mutation blocking ubiquitination signal	0.5278
p.A2V	ChaGo-K-1	lung	COSMIC	DYR	CBL_MET	11:13	Mutation blocking ubiquitination signal	0.5278
p.D20Y	SIDM00375	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	11:13	Mutation blocking ubiquitination signal	0.5833
p.D20Y	ACH-002305	Head and Neck Cancer	CCLE	DYR	CBL_MET	11:13	Mutation blocking ubiquitination signal	0.5833
p.D20Y	SKN-3	upper aerodigestive tract	COSMIC	DYR	CBL_MET	11:13	Mutation blocking ubiquitination signal	0.5833
p.L12V	ACH-001513	Cervical Cancer	CCLE	DYR	CBL_MET	11:13	Mutation altering degron motif	0.6765
p.E21D	NCI-H209	lung	COSMIC	DYR	CBL_MET	11:13	Mutation rewiring degron network	0.1111
p.D6Y	SKN-3	upper aerodigestive tract	COSMIC	DYR	CBL_MET	11:13	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc