DegronMD - P62508(ESRRG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S86L	TCGA-04-1542	OV	TCGA	PPLY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.M77T	TCGA-A5-A0GA	UCEC	TCGA	PPLY	ITCH	82:85	Mutation rewiring degron network	0.1944
p.P87L	TCGA-AD-6895	COAD	TCGA	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2778
p.P87L	SIDM01577	Plasma Cell Myeloma	GDSC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2778
p.P87L	ACH-000889	Myeloma	CCLE	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2778
p.L84R	TCGA-BR-A4QM	STAD	TCGA	PPLY	ITCH	82:85	Mutation altering degron motif	0.7316
p.P88L	TCGA-CD-A487	STAD	TCGA	PPLY	ITCH	82:85	Mutation rewiring degron network	0.25
p.G83E	TCGA-EE-A181	SKCM	TCGA	PPLY	ITCH	82:85	Mutation altering degron motif	0.7199
p.P94L	TCGA-EE-A3J5	SKCM	TCGA	PPLY	ITCH	82:85	Mutation rewiring degron network	0.0833
p.G83R	TCGA-FS-A4F5	SKCM	TCGA	PPLY	ITCH	82:85	Mutation altering degron motif	0.7568
p.D80N	DO51618	CESC	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2778
p.D80N	HCT-116	large intestine	COSMIC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2778
p.D88Y	DO10172	COAD	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.25
p.Q90L	DO23616	LUAD	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.1944
p.G72W	DO26782	LUSC	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.0556
p.P89S	DO45444	LUSC	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2222
p.P89S	DO41572	UCEC	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2222
p.P89A	DO219140	LUSC	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2222
p.P89L	DO30070	OV	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.2222
p.S81L	DO31729	OV	ICGC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.S83G	DO38192	STAD	ICGC	PPLY	ITCH	82:85	Mutation altering degron motif	0.6993
p.S83N	DO41241	UCEC	ICGC	PPLY	ITCH	82:85	Mutation altering degron motif	0.7069
p.S86P	SIDM01041	Esophageal Carcinoma	GDSC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.S86P	ACH-001500	Esophageal Cancer	CCLE	PPLY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.S86P	FLO-1	oesophagus	COSMIC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.I95T	SIDM01220	Glioma	GDSC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.0556
p.I95T	ACH-002269	Brain Cancer	CCLE	PPLY	ITCH	82:85	Mutation rewiring degron network	0.0556
p.I95T	LNZTA3WT4	central nervous system	COSMIC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.0556
p.L84P	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	PPLY	ITCH	82:85	Mutation altering degron motif	0.6471
p.L84P	ACH-000053	Lymphoma	CCLE	PPLY	ITCH	82:85	Mutation altering degron motif	0.6471
p.L84P	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	82:85	Mutation altering degron motif	0.6471
p.I90T	LNZTA3WT4	central nervous system	COSMIC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.1944
p.S81P	FLO-1	oesophagus	COSMIC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.L79P	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	82:85	Mutation rewiring degron network	0.25

Kaplan plot for ESRRG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ESRRG

UniProt ID: P62508

Entrez ID: 2104

Protein name: Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ESRRG in