DegronMD - P78332(RBM6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A77S	TCGA-13-0885	OV	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1389
p.A77S	DO30490	OV	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1389
p.D79N	TCGA-14-1037	GBM	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1944
p.D79N	DO14085	GBM	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1944
p.P81L	TCGA-36-2543	OV	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.25
p.P81L	DO32367	OV	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.25
p.G395V	TCGA-78-7166	LUAD	TCGA	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1944
p.G395V	DO25629	LUAD	ICGC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1944
p.R126W	TCGA-AA-A022	COAD	TCGA	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1111
p.R126W	DO10647	COAD	ICGC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1111
p.R126W	ACH-000829	Myeloma	CCLE	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1111
p.D400N	TCGA-AJ-A3I9	UCEC	TCGA	DYR	CBL_MET	400:402	Mutation altering degron motif	0.6932
p.D400N	DO42272	UCEC	ICGC	DYR	CBL_MET	400:402	Mutation altering degron motif	0.6932
p.D400Y	TCGA-AP-A056	UCEC	TCGA	DYR	CBL_MET	400:402	Mutation altering degron motif	0.7325
p.D400Y	DO43971	UCEC	ICGC	DYR	CBL_MET	400:402	Mutation altering degron motif	0.7325
p.R438W	TCGA-AZ-6598	COAD	TCGA	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.1667
p.R438W	DO10276	COAD	ICGC	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.1667
p.E89D	TCGA-BI-A0VS	CESC	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.25
p.E89D	DO6263	CESC	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.25
p.S142Y	TCGA-BS-A0UV	UCEC	TCGA	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142Y	TCGA-BS-A0UV	UCEC	TCGA	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.S142Y	DO42793	UCEC	ICGC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142Y	DO42793	UCEC	ICGC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.Q437K	TCGA-D3-A3CE	SKCM	TCGA	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.1389
p.Q437K	DO37405	SKCM	ICGC	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.1389
p.R126Q	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1111
p.R126Q	DO223286	UCEC	ICGC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1111
p.D134Y	TCGA-DU-6392	LGG	TCGA	DYR	CBL_MET	134:136	Mutation altering degron motif	0.7325
p.D134Y	DO22237	LGG	ICGC	DYR	CBL_MET	134:136	Mutation altering degron motif	0.7325
p.S403I	TCGA-EK-A2R9	CESC	TCGA	DYR	CBL_MET	400:402	Mutation blocking phosphorylation signal	0.75
p.S403I	DO51600	CESC	ICGC	DYR	CBL_MET	400:402	Mutation blocking phosphorylation signal	0.75
p.D94N	TCGA-GM-A2DO	BRCA	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1111
p.D94N	DO2037	BRCA	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1111
p.D408H	TCGA-K4-A83P	BLCA	TCGA	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1667
p.D408H	DO49787	BLCA	ICGC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1667
p.L391V	TCGA-MV-A51V	BLCA	TCGA	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.0833
p.L391V	DO474	BLCA	ICGC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.0833
p.F393Y	DO218404	BRCA	ICGC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1389
p.A403V	DO1749	BRCA	ICGC	DYR	CBL_MET	400:402	Mutation blocking phosphorylation signal	0.75
p.R128H	DO230346	COCA	ICGC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.G411V	DO234160	ESAD	ICGC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.0833
p.T399I	DO233245	GACA	ICGC	DYR	CBL_MET	400:402	Mutation blocking phosphorylation signal	0.75
p.G90V	DO228976	LICA	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.2222
p.R92L	DO229041	LICA	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1667
p.D127Y	DO229006	LICA	ICGC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1389
p.V400I	DO44854	LICA	ICGC	DYR	CBL_MET	400:402	Mutation altering degron motif	0.7076
p.L390R	DO46625	PAAD	ICGC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.0556
p.T404S	DO33070	PACA	ICGC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.2778
p.H152Y	DO229070	PRAD	ICGC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.1667
p.Q156H	DO51301	SKCM	ICGC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.0556
p.T145I	DO51759	STAD	ICGC	DYR	CBL_MET	144:146	Mutation altering degron motif	0.7078
p.S128L	DO48181	UCEC	ICGC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.R85I	DO42023	UCEC	ICGC	DYR	CBL_MET	84:86	Mutation altering degron motif	0.8102
p.I133R	DO42256	UCEC	ICGC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.3056
p.D77G	DO43907	UCEC	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1389
p.A452D	DO42673	UCEC	ICGC	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.1667
p.M74I	DO42673	UCEC	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.G88V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.2778
p.G88V	ACH-000924	Lung Cancer	CCLE	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.2778
p.G88V	NCI-H2172	lung	COSMIC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.2778
p.S142P	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142P	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.S142P	SIDM00461	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142P	SIDM00461	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.S142P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.S142P	SIDM01519	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142P	SIDM01519	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.S142P	ACH-000786	Lymphoma	CCLE	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142P	ACH-000786	Lymphoma	CCLE	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.S142P	ACH-000992	Head and Neck Cancer	CCLE	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142P	ACH-000992	Head and Neck Cancer	CCLE	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.A150T	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2222
p.A150T	SIDM01519	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2222
p.E405A	SIDM01109	Other Sarcomas	GDSC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.25
p.E405A	SIDM01060	Melanoma	GDSC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.25
p.G448D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.2778
p.G448D	ACH-002256	Leukemia	CCLE	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.2778
p.G448D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.2778
p.R96S	SIDM00139	Mesothelioma	GDSC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.R96S	ACH-000367	Lung Cancer	CCLE	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.R96S	NCI-H226	lung	COSMIC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.L394H	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1667
p.L394H	ACH-002220	Lymphoma	CCLE	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1667
p.L394H	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1667
p.S142C	SIDM00254	Neuroblastoma	GDSC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142C	SIDM00254	Neuroblastoma	GDSC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.S142C	NB5	autonomic ganglia	COSMIC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.S142C	NB5	autonomic ganglia	COSMIC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778
p.G390S	SIDM00793	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.0556
p.F393L	SIDM00118	Colorectal Carcinoma	GDSC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1389
p.F393L	ACH-001081	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1389
p.F393L	HCC2998	large intestine	COSMIC	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1389
p.G395W	ACH-001369	Ovarian Cancer	CCLE	DYR	CBL_MET	400:402	Mutation rewiring degron network	0.1944
p.S79P	HCT-15	large intestine	COSMIC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1944
p.R130Q	HCC2998	large intestine	COSMIC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.2222
p.A77G	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1389
p.R128C	HCT-15	large intestine	COSMIC	DYR	CBL_MET	134:136	Mutation rewiring degron network	0.1667
p.E400D	NUGC-3	stomach	COSMIC	DYR	CBL_MET	400:402	Mutation altering degron motif	0.6758
p.R86Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	84:86	Mutation altering degron motif	0.7329
p.S450C	H3118	upper aerodigestive tract	COSMIC	DYR	CBL_MET	444:446	Mutation rewiring degron network	0.2222
p.F148I	HCT-15	large intestine	COSMIC	DYR	CBL_MET	144:146	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM6

UniProt ID: P78332

Entrez ID: 10180

Protein name: RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM6 in