DegronMD - P78386(KRT85)

KRT85

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R505C	TCGA-A8-A079	BRCA	TCGA	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.R505C	DO4251	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.R492C	TCGA-EE-A29B	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.719
p.R492C	DO47255	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.719
p.P488L	TCGA-RC-A6M3	LIHC	TCGA	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.25
p.P488L	DO223914	LIHC	ICGC	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.25
p.D484G	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389
p.D484G	ACH-000782	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389
p.D484G	ACH-001735	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389
p.A482V	SIDM01619	Endometrial Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833
p.A482V	ACH-000984	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc