DegronMD - P78424(POU6F2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A437E	TCGA-06-0137	GBM	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0556
p.S455Y	TCGA-D3-A2JN	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.2222
p.S455Y	DO47590	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.2222
p.S451F	TCGA-EE-A29D	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.9093
p.S451F	TCGA-EE-A2GS	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.9093
p.S451F	DO37465	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.9093
p.S451F	DO38123	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.9093
p.S453A	TCGA-EO-A3AV	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.7222
p.S453A	DO52412	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.7222
p.S440Y	TCGA-EO-A3B0	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1389
p.S440Y	DO219773	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1389
p.Q441R	TCGA-FI-A2D5	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1667
p.Q441R	DO41331	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1667
p.P443L	TCGA-QC-A7B5	SARC	TCGA	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.2222
p.P443L	DO220239	SARC	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.2222
p.S450Y	DO222798	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.8231
p.A447S	DO229015	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.7588
p.S457F	DO229456	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1667
p.A461V	NALM-6	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0556
p.R439Q	SNU-407	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1111

Kaplan plot for POU6F2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POU6F2

UniProt ID: P78424

Entrez ID: 11281

Protein name: POU domain, class 6, transcription factor 2 (Retina-derived POU domain factor 1) (RPF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POU6F2 in