DegronMD - P78426(NKX6-1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G354C	TCGA-66-2770	LUSC	TCGA	PESSS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0833
p.L56V	DO223592	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.D51Y	DO222755	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.7325
p.D49Y	DO26749	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.7325
p.S49P	DO27484	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6752
p.G46S	DO222599	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.D57Y	DO31450	OV	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.E48Q	DO33091	PACA	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6744
p.G46A	DO38727	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.G46A	ACH-000943	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.D49E	DO38288	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6758
p.A45V	DO229213	THCA	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.2778
p.D50N	DO43971	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6932
p.A360T	SIDM00142	Endometrial Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.25
p.A360T	ACH-000864	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.25
p.A360T	COLO-684	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.25
p.P363L	SIDM00560	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7582
p.P363L	ACH-000678	Gastric Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7582
p.G355C	SIDM01173	Rhabdomyosarcoma	GDSC	PESSS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1111
p.S367P	ACH-000982	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.6752
p.S367P	ACH-001345	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.6752
p.S367P	GP5d	large intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.6752
p.S361P	ACH-002023	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for NKX6-1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NKX6-1

UniProt ID: P78426

Entrez ID: 4825

Protein name: Homeobox protein Nkx-6.1 (Homeobox protein NK-6 homolog A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NKX6-1 in