DegronMD - P80723(BASP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A199V	TCGA-05-4418	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.25
p.A199V	DO23814	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.25
p.A203T	TCGA-44-3396	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1389
p.A203T	DO23559	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1389
p.A203T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1389
p.A203T	H513	pleura	COSMIC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1389
p.S194I	TCGA-50-5049	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.8453
p.S194I	DO23705	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.8453
p.A206S	TCGA-AA-3697	COAD	TCGA	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.A206S	DO8424	COAD	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.T190M	TCGA-BR-A4J5	STAD	TCGA	APSST	DEG_SPOP_SBC_1	192:196	Mutation blocking phosphorylation signal	0.7222
p.T190M	DO38185	STAD	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation blocking phosphorylation signal	0.7222
p.A192V	DO228123	EOPC	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.5825
p.A203V	DO223051	ESCA	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1389
p.E191V	DO233198	GACA	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.3056
p.A199T	DO50840	LIRI	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.25
p.P197L	DO232761	PBCA	ICGC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.3056
p.A188T	SIDM00216	Colorectal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A188T	SIDM00835	Colorectal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A188T	ACH-000489	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A188T	ACH-000989	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A188T	ACH-002287	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A188T	SW1116	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A188T	SNU-175	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A188T	NCI-H630	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.A204G	SIDM00392	Melanoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.A204G	SIDM00681	Colorectal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.A204G	SIDM01641	Non-Cancerous	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.A204G	SIDM00930	Osteosarcoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.A204S	SIDM01051	Ovarian Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.A204S	ACH-000936	Ovarian Cancer	CCLE	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.A204S	EFO-27	ovary	COSMIC	APSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.K184R	SIDM01608	Endometrial Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	192:196	Mutation blocking ubiquitination signal	0.5556
p.K184R	ACH-000990	Endometrial/Uterine Cancer	CCLE	APSST	DEG_SPOP_SBC_1	192:196	Mutation blocking ubiquitination signal	0.5556

Kaplan plot for BASP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BASP1

UniProt ID: P80723

Entrez ID: 10409

Protein name: Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BASP1 in