DegronMD - P82650(MRPS22)

MRPS22

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T90S	TCGA-DK-A1A7	BLCA	TCGA	PPTY	ITCH	100:103	Mutation rewiring degron network	0.0556
p.T90S	DO483	BLCA	ICGC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.0556
p.P101S	TCGA-E6-A1LX	UCEC	TCGA	PPTY	ITCH	100:103	Mutation altering degron motif	0.6752
p.P101S	DO41020	UCEC	ICGC	PPTY	ITCH	100:103	Mutation altering degron motif	0.6752
p.A94V	DO234345	ESAD	ICGC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.1667
p.A94S	DO229028	LICA	ICGC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.1667
p.Q110H	DO229022	LICA	ICGC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.1389
p.K92N	DO229045	LICA	ICGC	PPTY	ITCH	100:103	Mutation blocking ubiquitination signal	0.5556
p.P101T	SIDM01169	Ovarian Carcinoma	GDSC	PPTY	ITCH	100:103	Mutation altering degron motif	0.7031
p.M106V	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.25
p.M106V	HCC-44	lung	COSMIC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.25
p.E93K	ACH-000902	Breast Cancer	CCLE	PPTY	ITCH	100:103	Mutation rewiring degron network	0.1389
p.E93K	ACH-002026	Endometrial/Uterine Cancer	CCLE	PPTY	ITCH	100:103	Mutation rewiring degron network	0.1389
p.E93K	CAL-148	breast	COSMIC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.1389
p.M105V	HCC-44	lung	COSMIC	PPTY	ITCH	100:103	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc