DegronMD - P84022(SMAD3)

GO - Biological processes (BP): activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell-cell junction organization [GO:0045216]; cell differentiation [GO:0030154]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; developmental growth [GO:0048589]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; embryonic pattern specification [GO:0009880]; endoderm development [GO:0007492]; extrinsic apoptotic signaling pathway [GO:0097191]; heart looping [GO:0001947]; immune response [GO:0006955]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; JNK cascade [GO:0007254]; lens fiber cell differentiation [GO:0070306]; liver development [GO:0001889]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung blood pressure [GO:0061767]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of wound healing [GO:0061045]; nodal signaling pathway [GO:0038092]; osteoblast development [GO:0002076]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta3 production [GO:0032916]; primary miRNA processing [GO:0031053]; protein stabilization [GO:0050821]; regulation of binding [GO:0051098]; regulation of epithelial cell proliferation [GO:0050678]; regulation of immune response [GO:0050776]; regulation of miRNA transcription [GO:1902893]; regulation of striated muscle tissue development [GO:0016202]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta2 production [GO:0032909]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein complex assembly [GO:0007183]; SMAD protein signal transduction [GO:0060395]; somitogenesis [GO:0001756]; T cell activation [GO:0042110]; thyroid gland development [GO:0030878]; transdifferentiation [GO:0060290]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E178D	TCGA-AA-3510	COAD	TCGA	PPGY	ITCH	181:184	Mutation rewiring degron network	0.25
p.E178D	TCGA-AG-A002	READ	TCGA	PPGY	ITCH	181:184	Mutation rewiring degron network	0.25
p.H194P	DO51078	PRAD	ICGC	PPGY	ITCH	181:184	Mutation rewiring degron network	0.0556
p.P172T	SIDM00625	Other Sarcomas	GDSC	PPGY	ITCH	181:184	Mutation rewiring degron network	0.0833
p.P172T	MES-SA	soft tissue	COSMIC	PPGY	ITCH	181:184	Mutation rewiring degron network	0.0833
p.P177A	SIDM01520	Oral Cavity Carcinoma	GDSC	PPGY	ITCH	181:184	Mutation rewiring degron network	0.2222
p.P177A	ACH-000503	Head and Neck Cancer	CCLE	PPGY	ITCH	181:184	Mutation rewiring degron network	0.2222
p.P180L	ACH-002396	Bone Cancer	CCLE	PPGY	ITCH	181:184	Mutation rewiring degron network	0.3056
p.P180L	Sarc9371	bone	COSMIC	PPGY	ITCH	181:184	Mutation rewiring degron network	0.3056
p.V182I	NUGC-4	stomach	COSMIC	PPGY	ITCH	181:184	Mutation altering degron motif	0.7076
p.K183E	SW900	lung	COSMIC	PPGY	ITCH	181:184	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMAD3

UniProt ID: P84022

Entrez ID: 4088

Protein name: Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMAD3 in