DegronMD - P84103(SRSF3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P100S	TCGA-21-1079	LUSC	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.25
p.P100S	DO26846	LUSC	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.25
p.D102Y	TCGA-AP-A051	UCEC	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.3056
p.D102Y	DO42673	UCEC	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.3056
p.R113C	TCGA-AP-A0LM	UCEC	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.1111
p.R113C	DO43306	UCEC	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.1111
p.R99H	TCGA-EC-A1QX	UCEC	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	TCGA-EY-A549	UCEC	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	DO52450	COCA	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	DO48174	UCEC	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	DO42592	UCEC	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	ACH-001127	Leukemia	CCLE	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R99H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2222
p.R105C	TCGA-EE-A181	SKCM	TCGA	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8301
p.R105C	DO48395	BLCA	ICGC	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8301
p.R105C	DO37444	SKCM	ICGC	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8301
p.P94S	TCGA-FS-A1ZZ	SKCM	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0833
p.P94S	DO220851	MELA	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0833
p.P94S	DO37412	SKCM	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0833
p.W96C	DO229027	LICA	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.1389
p.R98L	DO229264	THCA	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.1944
p.R98C	SIDM02026	Colorectal Carcinoma	GDSC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.1944
p.S115F	SIDM01511	Gastric Carcinoma	GDSC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0556
p.S115F	ACH-000746	Gastric Cancer	CCLE	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0556
p.R107S	ACH-000923	Lymphoma	CCLE	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.2778

Kaplan plot for SRSF3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRSF3

UniProt ID: P84103

Entrez ID: 6428

Protein name: Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SRSF3 in