DegronMD - Q00975(CACNA1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2184H	TCGA-2J-AABI	PAAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0556
p.D2131H	TCGA-78-7156	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation rewiring degron network	0.0556
p.R2198S	TCGA-95-7043	LUAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.6316
p.R2198S	TCGA-FS-A1ZH	SKCM	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.6316
p.R2198S	TCGA-H2-A26U	THCA	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.6316
p.S2122L	TCGA-A5-A2K5	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation rewiring degron network	0.3056
p.R2198H	TCGA-AX-A2HG	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	TCGA-B5-A11E	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	TCGA-D5-6927	COAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	SIDM01274	Esophageal Carcinoma	GDSC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	SIDM01943	Colorectal Carcinoma	GDSC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.P2194S	TCGA-B5-A11E	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.6752
p.D2131N	TCGA-B5-A1MR	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation rewiring degron network	0.0556
p.G2185S	TCGA-D1-A168	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0833
p.G2185S	TCGA-HU-A4GX	STAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0833
p.R2188K	TCGA-ER-A19O	SKCM	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.1667
p.T2193K	TCGA-G2-AA3F	BLCA	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.3056
p.P2197L	TCGA-RD-A7C1	STAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7582
p.T2191K	DO51885	BLCA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.25
p.R2196H	DO10332	COAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.R2196H	DO33432	PACA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.R2196H	DO41644	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.R2196H	DO41337	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.R2108W	DO222519	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation rewiring degron network	0.0833
p.T2209M	DO222866	COCA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0833
p.D2129N	DO233108	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation blocking phosphorylation signal	0.5556
p.D2129N	DO41758	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation blocking phosphorylation signal	0.5556
p.R2185Q	DO233888	GACA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0833
p.R2130L	DO229026	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation rewiring degron network	0.0833
p.D2129H	DO23720	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation blocking phosphorylation signal	0.5556
p.R2196S	DO24739	LUAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7427
p.R2196S	DO37575	SKCM	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7427
p.R2196S	DO40045	THCA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7427
p.E2121D	DO50727	ORCA	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation altering degron motif	0.6758
p.R2186K	DO38063	SKCM	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.1111
p.P2195L	DO50132	STAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7582
p.P2192S	DO41644	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.2778
p.R2124H	DO41199	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation substituting flanking lysine	0.3611
p.G2199D	DO42793	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7198
p.R2130C	DO42713	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation rewiring degron network	0.0833
p.I2209T	DO42665	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0833
p.S2120L	DO41379	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation altering degron motif	0.7667
p.S2120C	SIDM00040	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation altering degron motif	0.7541
p.R2110L	ACH-000829	Myeloma	CCLE	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation rewiring degron network	0.1389
p.P2117S	ACH-001664	Gastric Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation altering degron motif	0.6752
p.S2184T	YAPC	pancreas	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0556
p.S2184T	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0556
p.S2184T	SCC-3	haematopoietic and lymphoid tissue	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0556
p.S2184T	AMO-1	haematopoietic and lymphoid tissue	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation rewiring degron network	0.0556
p.L2194M	NCI-H2342	lung	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.711

Kaplan plot for CACNA1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1B

UniProt ID: Q00975

Entrez ID: 774

Protein name: Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNA1B in