DegronMD - Q00975(CACNA1B)

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell deat... View more >>

GO - Biological processes (BP): calcium ion import [GO:0070509]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; regulation of ion transmembrane transport [GO:0034765]; response to amyloid-beta [GO:1904645]

GO - Molecular function (MF): amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; protein C-terminus binding [GO:0008022]; voltage-gated calcium channel activity [GO:0005245]

GO - Cellular component (CC): plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PLTPRPS	DEG_SCF_FBW7_1	FBXW7	Voltage-dependent N-type calcium channel subunit alpha-1B	2194:2200	More..
PSSSS	DEG_SPOP_SBC_1	SPOP	Voltage-dependent N-type calcium channel subunit alpha-1B	2117:2121	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2196H	DO10332	COAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.R2196H	DO33432	PACA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.R2196H	DO41644	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.R2196H	DO41337	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.8244
p.S2120L	DO41379	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation altering degron motif	0.7667
p.P2197L	TCGA-RD-A7C1	STAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7582
p.P2195L	DO50132	STAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7582
p.S2120C	SIDM00040	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation altering degron motif	0.7541
p.R2196S	DO24739	LUAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7427
p.R2196S	DO37575	SKCM	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7427
p.R2196S	DO40045	THCA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7427
p.G2199D	DO42793	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7198
p.R2198H	TCGA-AX-A2HG	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	TCGA-B5-A11E	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	TCGA-D5-6927	COAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	SIDM01274	Esophageal Carcinoma	GDSC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.R2198H	SIDM01943	Colorectal Carcinoma	GDSC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.7133
p.L2194M	NCI-H2342	lung	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.711
p.E2121D	DO50727	ORCA	ICGC	PSSSS	DEG_SPOP_SBC_1	2117:2121	Mutation altering degron motif	0.6758
p.P2194S	TCGA-B5-A11E	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	2194:2200	Mutation altering degron motif	0.6752

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No resistance data available for this Degron.

Kaplan plot for CACNA1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1B

UniProt ID: Q00975

Entrez ID: 774

Protein name: Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for CACNA1B in