DegronMD - Q01543(FLI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S420L	TCGA-44-3398	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.S420L	DO25030	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.A419V	TCGA-58-A46M	LUSC	TCGA	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.A419V	DO45485	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.S406F	TCGA-69-8253	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.25
p.S406F	DO23637	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.25
p.F416V	TCGA-A5-A0G1	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.25
p.F416V	DO42472	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.25
p.V401A	TCGA-AX-A1CE	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1111
p.V401A	DO42280	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1111
p.F415L	TCGA-BS-A0UV	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.2778
p.F415L	DO42793	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.2778
p.P403H	DO224668	COCA	ICGC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.A419T	SIDM01469	Pancreatic Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.V411M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7208
p.N408D	A431	skin	COSMIC	PVTSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.3056

Kaplan plot for FLI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLI1

UniProt ID: Q01543

Entrez ID: 2313

Protein name: Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FLI1 in